Risk factors for corneal graft failure and rejection in penetrating ｋeratoplasty

Abstract:

to evaluate risk factorsof graft failure and allograft rejection after Penetrating keratoPlasty (PK). ·METHODS: Clinical dataof PKson 224 eyes (212 Patients) from 1996to 2006 were studied retrosPectively.the graft survival rate and rejection-free survival rateover 10 years were estimated with KaPlan-Meir's lifetable, and differences between levelsof each factor were comPared with log-ranktest. Cox regression was also Performedto further assessthe imPactof related clinical factorsonthe Prognosisofthe corneal graft. ·RESULTS:theoverall ratesof graft survival and rejection-free graft survival at 10 years after PK were 81.4% and 78.2% resPectively. Relatively higher riskof graft failure was associated with corneal vascularization, regraft, aPhakiaor PseudoPhakia, Presenceof anterioror Posterior synechia, long (≥90 minutes )oPerationtime andolder (≥60 years) ageof reciPient. Relatively higher riskof rejection was associated with corneal vascularization and longoPerationtime. Cox regression analysis showed corneal vascularization（RR = 2.46, P =0.04）, regraft (RR =5.67,P <0.01), aPhakia (RR = 3.64,P <0.05),or PseudoPhakia (RR =6.83,P <0.01), Presenceof anterior (RR =2.76,P = 0.05)or Posterior synechia (RR =3.12, P =0.05) were indePendent risk factors for corneal graft failure. ·CONCLUSION:the risk factors for graft failure after PK were corneal vascularization, regraft, aPhakiaor PseudoPhakia, Presenceof anterioror Posterior synechia.the risk factors after PK for allograft rejection were corneal vascularization and longoPerationtime.

Key words:Penetraing keratoPlasty; graft failure; allograft rejection; risk factor