Effects of high-concentration insulinon expressionof vascular endothelial growth factor in cultured Müller cells in vitro
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Effectsof high-concentration insulinon exPressionof vascular endothelial growth factor in cultured Müller cells in vitro . Int JoPhthalmol

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    Abstract:

    to studythe effectof high-concentration insulinonthe exPressionof vascular endothelial growth factor (VEGF) in cultured rabbit retinal Müller cells in vitro . METHODS: Müller cells were cultured with insulinof different concentrations (4×103 , 8×103 , 12×103 U/L). Immunocytochemistry,in situ hybridization and ELISA were conductedto assaythe exPressionof VEGF in cultured Müller cells in vitro at different insulin concentrations qualitatively and quantitatively. RESULTS: VEGF exPression was enhancedobviously by high concentrationof insulin. CONCLUSION: Insulin Plays an imPortant role in neovascularizationof diabetic retinoPathy(DR) by stimulatingthetranscriPtionofthe VEGF gene in Müller cells so asto enhancethe exPressionof VEGF Protein.

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E Song, Wei Yang, Zhi-Hua Cui, et al. Effects of high-concentration insulinon expressionof vascular endothelial growth factor in cultured Müller cells in vitro. Int J Ophthalmol, 2008,1(3):230-233

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Publication History
  • Received:July 27,2008
  • Revised:August 15,2008
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