Abstract:To summarize the clinical features of Chinese primary congenital glaucoma(PCG) and to investigate the discrepancies of the clinical features between the Chinese and Indian patients. · METHODS: Clinical records of 40 Chinese PCG patients were reviewed. The clinical features were summarized as several quantifiable clinical parameters and the severity of the disease was evaluated. Both the quantified clinical features and severity were statistically compared with those of the Indian patients, which were cited from the previously published articles. · RESULTS: Forty Chinese and 43 Indian patients were included in the study. In Chinese patients, sex ratio (male to female )was about 2:1, family history was presented in 3 patients(7.5%) and consanguinity was found in one patient (2.5%). The main symptoms and signs observed in Chinese patients spanned a wide spectrum of manifestations. The most frequent signs noted in the initial examination were enlarged eyeball (42.5%) and decreased visual acuity(VA)(35.0%). Compared with Indian patients, Chinese patients had a later onset, a delayed diagnosis , more severe corneal changes and more severe optic nerve damages(P <0.01). The combined trabeculectomy and trabeculotomy operation was preferred by both Chinese and Indian doctors whereas a higher proportion of Indian patients received the combined operation (P <0.01). The proportions of the severity grade were different between Chinese and Indian patients. Most Chinese patients were in the severe grade while most Indian patients were in the very severe grade (P <0.01). · CONCLUSION: Chinese PCG patients were sporadic and non-consanguineous. Compared with Indian patients, Chinese patients had a relative later onset, a delayed diagnosis and treatment. More attempts are needed in Chinese PCG prevention and treatment.
