The inhibitory effect of triamcinolone acetonide on the proliferation of monkey choroid-retinal endothelial cells in hypoxia condition
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The inhibitory effect of triamcinolone acetonide on the proliferation of monkey choroid- retinal endothelial cells in hypoxia condition. Int J Ophthalmol

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    Abstract:

    To observe the inhibitory effect of triamcinolone acetonide (TA) on the proliferation of monkey choroid- retinal endothelial cells (RF/6A) in hypoxia or normal conditions. · METHODS: TA was added into the cultured RF/6A of rhesus monkey. The effect of TA on the cellular activity was observed by MTT, the effect on cellular proliferation and apoptosis was detected by flow cytometry (FCM). · RESULTS: The numbers of cells in s-phase of a cell cycle were reduced and the proportion of cells in G2-M phase was increased under the hypoxia condition. TA had a great effect on the cell cycle of RF/6A of rhesus monkey and it induced apoptosis of endothelial cells. It relatively increased the s-phase cells and reduced G2-M phase cells under both normal and hypoxia conditions, which indicates its role in blocking cell cycle from s-phase to G2-M phase and reducing mitosis. · CONCLUSION: Hypoxia promotes the proliferation of RF/6A cells while TA has the opposite effect in both normal and hypoxia conditions. TA can also induce apoptosis of endothelial cells.

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Jian-Hua Xu, Zhe-Li Liu, Ruo-Xi Li, et al. The inhibitory effect of triamcinolone acetonide on the proliferation of monkey choroid-retinal endothelial cells in hypoxia condition. Int J Ophthalmol, 2008,1(1):38-41

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Publication History
  • Received:December 06,2007
  • Revised:February 18,2008
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