[关键词]
[摘要]
泛凋亡是一种新型的炎症性程序性细胞死亡(PCD)方式，它涉及细胞焦亡、凋亡和坏死性凋亡的关键分子特征，但并非其简单叠加。其主要特征为细胞膜完整性破坏，并释放大量炎症因子及损伤相关分子模式。这些过程在调节免疫反应和组织损伤中起着重要作用。既往研究主要关注泛凋亡在肿瘤、感染性及炎症性疾病中的作用，其在眼部疾病中的研究仍相对有限。文章综述泛凋亡在青光眼、糖尿病视网膜病变、年龄相关性黄斑变性和角膜炎等眼病中的现有证据，为进一步认识其潜在作用及机制提供参考。
[Key word]
[Abstract]
PANoptosis is a newly recognized form of inflammatory programmed cell death(PCD)that involves key molecular features of pyroptosis, apoptosis, and necroptosis, rather than a simple combination of these pathways. It is characterized primarily by loss of plasma membrane integrity and the subsequent release of inflammatory cytokines and damage-associated molecular patterns, thereby contributing to immune regulation and tissue injury. Previous studies have mainly focused on the roles of PANoptosis in cancer, infectious diseases, and inflammatory disorders, while research on its application in ocular diseases is still relatively limited. This review summarizes the current evidence regarding PANoptosis in ocular diseases, including glaucoma, diabetic retinopathy, age-related macular degeneration, and keratitis, and may provide a reference for further investigation into its potential roles and underlying mechanisms.
[中图分类号]
[基金项目]
河南省医学科技攻关计划项目(No.LHGJ20230515); 新乡市科技攻关计划项目(No.GG2021030)
