[关键词]
[摘要]
577 nm阈值下微脉冲激光(577 nm SML)是一种非损伤性视网膜激光治疗技术，通过选择性作用于视网膜色素上皮(RPE)，诱导热休克蛋白表达，调节炎症反应，促进血-视网膜屏障修复，降低血管内皮生长因子(VEGF)水平，改善Müller细胞功能，从而促进视网膜代谢及功能恢复，同时避免传统阈值激光引起的热损伤。近年来，577 nm SML已广泛应用于中心性浆液性脉络膜视网膜病变(CSC)、糖尿病性黄斑水肿(DME)、视网膜静脉阻塞继发黄斑水肿(RVO-ME)、年龄相关性黄斑变性(ARMD)、2型黄斑毛细血管扩张症(MacTel2)、视网膜脱离术后持续性视网膜下液及Irvine-Gass综合征等多种眼底疾病，具有良好的安全性、可重复性和较高的临床应用价值，并可作为抗VEGF治疗的重要辅助或补充手段。文章旨在总结577 nm SML治疗原理及常见眼底疾病中的应用以便为后续临床应用提供理论依据。
[Key word]
[Abstract]
The 577 nm subthreshold micropulse laser(577 nm SML)is a non-invasive retinal laser treatment technique that selectively acts on the retinal pigment epithelium(RPE), induces heat shock protein expression, regulates inflammatory response, promotes blood retinal barrier repair, downregulates vascular endothelial growth factor(VEGF)levels, improves Müller cell function, promotes retinal metabolism and functional recovery, and avoids thermal damage caused by traditional threshold lasers. In recent years, 577 nm SML has been widely used in the treatment of various fundus diseases, including central serous chorioretinopathy(CSC), diabetes macular edema(DME), macular edema secondary to retinal vein occlusion(RVO-ME), age-related macular degeneration(ARMD), type 2 macular telangiectasia(MacTel2), persistent subretinal fluid after retinal detachment repair, and Irvine-Gass syndrome. Characterized by favorable safety and repeatability, 577 nm SML possesses high clinical application value and serves as a vital adjuvant and complementary strategy for anti-VEGF therapy. This review aims to summarize the therapeutic mechanisms and clinical applications of 577 nm SML in common fundus diseases, and provide a theoretical basis for its further clinical application.
[中图分类号]
[基金项目]
昆明市卫生健康委员会卫生科研课题项目(No.2025-07-02-025)
