[关键词]
[摘要]
黏蛋白是一类大分子、高度糖基化的蛋白质，在维持眼表稳态、泪膜稳定性及眼表屏障中发挥重要作用。文章系统综述了近年来黏蛋白相关的临床与基础研究进展，归纳其在维持眼表健康及参与眼表疾病的发生、发展中的作用，并总结现有黏蛋白的检测方法及以黏蛋白为靶点的治疗策略。重点探讨不同亚型干眼、其他眼表疾病及眼表手术后黏蛋白表达变化，以期为黏蛋白相关眼表疾病的诊断、评估和治疗提供参考。
[Key word]
[Abstract]
Mucins are a class of large, highly glycosylated proteins that play a critical role in maintaining ocular surface homeostasis, tear film stability and the ocular surface barrier. This article provides a systematic review of recent advances in clinical and basic research on mucins, summarizing their role in maintaining ocular surface health and their involvement in the onset and progression of ocular surface diseases. It also reviews current methods for detecting mucins and therapeutic strategies targeting mucins. Particular emphasis is placed on examining changes in the mucin expression profile in different subtypes of dry eye, ocular surface diseases and following ocular surface surgery, with the aim of providing guidance for the diagnosis, assessment and treatment of mucin-related ocular surface diseases.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.82074495); 上海市东方英才计划拔尖项目(No.2024DFYC); 上海市普陀区中心医院匠才计划项目(No.2022-RCJC-06)
