[关键词]
[摘要]
巩膜细胞外基质(ECM)的自我重塑是近视发生中的一个显著特征变化，同样影响着近视的发展进程。巩膜重塑发生机制复杂，转化生长因子-β(TGF-β)及其信号通路在其中起关键作用。文章对巩膜细胞外基质的主要代谢变化、TGF-β信号通路的分子机制及其在近视中参与巩膜重塑的调控作用进行综述，为近视的治疗和预防提供新的思路与策略。
[Key word]
[Abstract]
The self-remodeling of scleral extracellular matrix(ECM)is a significant characteristic alterationin the development of myopia, and it also influences the progression of myopia. The mechanisms of scleral remodeling are intricate, with transforming growth factor-β(TGF-β)and its associated signaling pathways playing a pivotal role. This review systematically summarizes the major metabolic changes in scleral ECM, the molecular mechanisms of the TGF-β signaling pathway, and its regulatory effects on scleral remodeling during myopic development, aiming to provide new insights and potential strategies for the treatment and prevention of myopia.
[中图分类号]
[基金项目]
四川省中央引导地方科技发展专项项目(No.2023ZYD0062); 衰老机制与干预四川省重点实验室(No.24LHFYSZ1-13)
