[关键词]
[摘要]
脉络膜血管指数(CVI)是一种基于OCT影像的结构性定量指标，可通过血管腔面积与总脉络膜面积之比表征脉络膜血管腔与基质的结构比例变化，并在一定程度上间接提示脉络膜状态的改变。随着增强深部成像光相干断层扫描(EDI-OCT)技术的发展，CVI在眼科临床实践中的应用日益广泛。CVI的测量具有良好的重复性和可靠性，加上EDI-OCT检查的无创性特点，使其成为眼科临床研究和日常诊疗工作中一个极具价值的评估工具。CVI可用于量化脉络膜血管腔面积与总脉络膜面积的比例变化，较单纯脉络膜厚度更能反映脉络膜血管与基质成分的相对改变。近年来，CVI已被广泛应用于年龄相关性黄斑变性(ARMD)、中心性浆液性脉络膜视网膜病变(CSC)、糖尿病视网膜病变(DR)、高度近视等疾病。除了疾病本身之外，一些眼部的手术或操作也会对CVI产生影响。现有研究提示，CVI变化可能与术后炎症反应、脉络膜血流动力学改变、血管通透性变化及眼压波动等因素相关，但不同研究在变化方向、持续时间及其与视功能预后的关系方面仍存在一定差异。文章综述眼部手术或操作对CVI的影响，并进一步分析其临床解释价值、现有争议及未来研究方向，以期为围手术期脉络膜结构评估和预后判断提供参考。
[Key word]
[Abstract]
The choroidal vascularity index(CVI)is a quantitative structural parameter derived from optical coherence tomography(OCT)images. It is defined as the ratio of the luminal area to the total choroidal area, which characterizes alterations in the structural proportion between choroidal vascular lumens and stroma, and indirectly indicates changes in choroidal status to a certain extent. With the development of enhanced depth imaging optical coherence tomography(EDI-OCT), CVI has been increasingly applied in ophthalmic research and clinical practice.Measurements of CVI exhibit excellent repeatability and reliability. Combined with the noninvasive nature of EDI-OCT, CVI is an extremely valuable assessment tool for clinical ophthalmic research and routine clinical practice. CVI can quantify proportional changes between the choroidal luminal area and total choroidal area, and better reflects relative variations in choroidal vascular and stromal components compared with choroidal thickness alone. In recent years, CVI has been widely applied to multiple ocular diseases including age-related macular degeneration(ARMD), central serous chorioretinopathy(CSC), diabetic retinopathy(DR), and high myopia. In addition to the diseases themselves, various ocular surgeries and procedures can also affect CVI. Current evidence suggests that changes in CVI may be associated with factors such as postoperative inflammatory response, choroidal hemodynamic alterations, vascular permeability changes, and intraocular pressure fluctuations. However, discrepancies remain among studies regarding the direction and duration of these changes and their relationship with visual outcomes. This review summarizes the effects of ocular surgeries and procedures on CVI and further discusses its clinical interpretation, existing controversies, and future research directions, aiming to provide a reference for perioperative assessment of choroidal structural changes and prognostic evaluation.
[中图分类号]
[基金项目]
无锡市“双百” 中青年医疗卫生拔尖人才培养计划(No.BJ2023037); 中国健康促进基金会科研发展公益项目(No.2025-ZCXY-0455)
