[关键词]
[摘要]
细胞外囊泡(EVs)是细胞分泌的纳米级膜泡，携带蛋白质、核酸等生物活性分子，在细胞间通讯中发挥关键作用，近年来在角膜及眼表疾病的诊断与治疗中显示出重要潜力。作为诊断标志物，泪液等来源的EVs可反映疾病特征，为疾病早期识别提供依据。在治疗方面，间充质干细胞(MSCs)来源EVs通过递送miRNA，调控炎症通路，促进角膜上皮修复并抑制纤维化。此外，EVs作为天然药物载体，可实现精准递送并促进角膜损伤愈合。文章系统总结了EVs在该领域的最新研究进展。
[Key word]
[Abstract]
Extracellular vesicles(EVs)are nanoscale membrane vesicles released by cells that carry bioactive molecules such as proteins and nucleic acids. They play a key role in intercellular communication. In recent years, they have shown significant potential in the diagnosis and treatment of corneal and ocular surface diseases. As diagnostic biomarkers, EVs derived from tears or other sources can reflect disease-specific characteristics, providing a basis for the early disease detection. In terms of therapy, mesenchymal stem cells(MSCs)-derived EVs deliver miRNAs to modulate inflammatory pathways, promote corneal epithelial repair, and inhibit fibrosis. Furthermore, as natural drug vehicles, EVs enable precise delivery of therapeutic agents and promote corneal wound healing. This review systematically summarizes the recent research advances in the application of EVs in the field.
[中图分类号]
[基金项目]
潍坊市科技发展计划项目(No.2025ZJ1121,2023YX067,2025RKX060)
