[关键词]
[摘要]
双调蛋白(AREG)是表皮生长因子家族成员，作为表皮生长因子受体(EGFR)的关键配体，可激活PI3K/Akt、ERK1/2及STAT3等信号通路，参与细胞增殖、凋亡抑制及炎症免疫调控等生物过程。AREG与眼部疾病密切相关，在角膜修复、视网膜损伤改善及眼轴增长调控中发挥重要作用。文章概述AREG的结构、分布及生物学功能，重点阐述其在眼科疾病中的调控机制：通过驱动上皮增厚与慢性炎症参与干燥综合征相关干眼； 经免疫-上皮协同机制促进角膜修复； 异常激活EGFR/PI3K通路导致晶状体混浊； 通过视网膜-巩膜信号轴调控眼轴延长； 调节小胶质细胞极化影响糖尿病视网膜病变进程； 通过表观遗传修饰增强眼部肿瘤耐药性。文章系统综述AREG在眼科疾病中的分子调控机制，旨在探讨其在眼科疾病临床应用中的潜力。
[Key word]
[Abstract]
Amphiregulin(AREG)is a member of the epidermal growth factor family. As a key ligand of the epidermal growth factor receptor(EGFR), it can activate signaling pathways such as PI3K/Akt, ERK1/2, and STAT3, participating in biological processes such as cell proliferation, apoptosis inhibition, and inflammatory immune regulation. AREG is closely related to ocular diseases and plays an important role in corneal repair, improvement of retinal damage, and regulation of ocular axial length. This article summarizes the structure, distribution, and biological functions of AREG, focusing on its regulatory mechanisms in ophthalmic diseases: participating in dry eye disease associated with Sjögren's syndrome by driving epithelial thickening and chronic inflammation; promoting corneal repair through an immune-epithelial coordination mechanism; abnormally activating the EGFR/PI3K pathway leading to lens opacity; regulating ocular axial length elongation through the retinal-scleral signal axis; modulating microglial polarization affecting the progression of diabetic retinopathy; and enhancing ocular tumor drug resistance through epigenetic modification. This article systematically reviews the molecular regulatory mechanisms of AREG in ophthalmic diseases, aiming to explore its potential for clinical application in ophthalmic diseases.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.82405486); 国家资助博士后研究人员计划(No.GZC20231505); 中国博士后科学基金(No.2024T170532); “泰山学者”项目专项基金(No.tsqnz20231252); 山东省自然科学基金项目(No.ZR2020MH393,ZR2025QC1751,ZR2024QH003); 山东省医药卫生科技项目(No.202307021591); 2024山东省中医药科技项目基金项目(No.M20242001); 山东中医药大学临床科研专项(No.LCKY202432); 2024年山东中医药大学第二批科学研究基金自然科学青年项目(No.KYZK2024Q15)
