[关键词]
[摘要]
甲状腺激素(TH)是甲状腺分泌的含碘酪氨酸衍生物，可促进糖脂代谢，并通过调控细胞增殖、分化、凋亡等生物学行为参与机体多种生理病理过程。近年来研究发现，TH在眼眶、视网膜、巩膜等眼组织的异常表达可通过调控眼眶软组织脂肪分化、视网膜氧化应激及后极部巩膜细胞外基质(ECM)降解等生物学进程，参与格雷夫斯眼病(GO)、年龄相关性黄斑变性(ARMD)、糖尿病视网膜病变(DR)、近视等眼病的发生发展。文章就TH在眼科疾病中的作用机制及相关研究进展进行综述，以期为眼科疾病的预防和治疗提供理论依据。
[Key word]
[Abstract]
Thyroid hormone(TH)is an iodinated derivative of the amino acid tyrosine secreted by the thyroid gland.It promotes glycolipid metabolism and is involved in various physiological and pathological processes by regulating cellular behaviors, such as cell proliferation, differentiation, and apoptosis. Recent studies have found that aberrant expression of TH in the orbit, retina, and sclera, and other ocular tissues can induce abnormal differentiation of orbital soft tissue adipocytes, alteration of retinal oxidative stress, and degradation of posterior scleral extracellular matrix(ECM), which contributes to the pathogenesis of many ophthalmic diseases, including Graves ophthalmopathy(GO), age-related macular degeneration(ARMD), diabetic retinopathy(DR), and myopia. This article reviews the role and mechanism of TH in various ophthalmic diseases, aiming to provide theoretical basis for the prevention and treatment of these ocular disorders.
[中图分类号]
[基金项目]
山东省重点研发计划项目(No.2021LCZX09)
