目的：探究强脉冲光联合普拉洛芬滴眼液对小儿睑板腺囊肿治疗效果及预后情况。

方法：选取2023年4月至2024年10月期间来我院就诊治疗的睑板腺囊肿患儿。依据数字表法随机将所有研究对象分组，对照组患者采用热敷治疗，药物组患者采用普拉洛芬滴眼液联合热敷治疗，激光组患者强脉冲光联合热敷治疗，联合组患者采用普拉洛芬滴眼液联合强脉冲光及热敷治疗。对比各组患儿治疗有效率、囊肿体表面积、眼部症状评分、不良反应发生情况。

结果：本研究纳入患儿80例80眼，对照组、药物组、激光组、联合组各20例20眼。对照组年龄7.49±1.09岁，男9例，女11例。药物组年龄7.63±0.98岁，男11例，女9例。激光组年龄7.39±0.59岁，男12例，女8例。联合组7.63±1.21岁，男12例，女8例。联合组睑板腺囊肿患儿治疗有效总人数为14例(70%)，明显高于对照组、药物组和激光组(均P<0.05)。治疗后，各组睑板腺囊肿患儿囊肿体表面积和眼部症状评分均发生不同程度降低，其中治疗后21 d，联合组患儿囊肿体表面积和眼部症状评分明显低于对照组、药物组和激光组(均P<0.05)。联合组患儿无不良反应，低于对照组、药物组和激光组，各组不良反应无差异(P>0.05)。

结论：强脉冲光联合普拉洛芬滴眼液可改善睑板腺囊肿患儿眼部症状，缩小睑板腺囊肿体表面积，提高临床治愈率，且该治疗方式安全性高。

METHODS: Children with meibomian gland cysts visited the hospital for treatment from April 2023 to October 2024 were selected as the research subjects. All subjects were grouped using the random number table methed. In the control group, patients were treated with hot compress. In the drug group, patients were treated with pralprofen eye drops combined with hot compress. In the laser group, patients were treated with intense pulsed light combined with hot compress. In the combination group, patients were treated with pralprofen eye drops combined with intense pulsed light and hot compress. The treatment effective rate, cyst surface area, ocular symptom score, and occurrence of adverse reactions of children in each group were compared.

RESULTS: A total of 80 children(80 eyes)were enrolled in this study, with 20 cases(20 eyes)in each of the control group, drug group, laser group, and combination group. The mean age was 7.49±1.09 y in the control group(9 males and 11 females), 7.63±0.98 y in the drug group(11 males and 9 females), 7.39±0.59 y in the laser group(12 males and 8 females), and 7.63±1.21 y in the combination group(12 males and 8 females). The total effective rate was 70%(14/20)in the combination group, which was significantly higher than that in the control group, drug group, and laser group(all P<0.05). After treatment, the cyst surface area and ocular symptom scores decreased to varying degrees in all groups. Notably, at 21 d post-treatment, the cyst surface area and ocular symptom scores in the combination group were significantly lower than those in the control group, drug group, and laser group(all P<0.05). No adverse reactions occurred in the combination group, which was lower than that in the control group, drug group, and laser group, with no statistically significant difference among the four groups(P>0.05).

CONCLUSION: Intense pulsed light combined with pralprofen eye drops can improve the ocular symptoms of children with meibomian gland cysts, reduce the surface area of meibomian gland cysts, increase the clinical cure rate, and this treatment method is highly safe.