[关键词]
[摘要]
目的:评价小剂量睫状体光凝治疗闭角型青光眼急性发作后持续高眼压的安全性及有效性。
方法:回顾性研究,收集2023年9月至2024年9月于联勤保障部队第九八八医院确诊为闭角型青光眼急性发作后持续高眼压的患者,采用半导体二极管激光经巩膜行小剂量睫状体光凝治疗,待眼压稳定后行白内障联合房角分离手术。比较光凝前后前房深度变化、光凝前后及超乳前后视力及眼压变化,并观察光凝后并发症发生情况。
结果:纳入患者21例21眼,其中男8例,女13例,平均年龄67.95±7.25岁。患者光凝后3 d前房深度1.49±0.18 mm相较光凝前1.22±0.21 mm增加(P<0.001); 光凝后1 d、超乳前、超乳后1 wk、超乳后1 mo相较光凝前的BCVA和IOP均下降(均P<0.01)。术后并发症方面,2眼术后当天出现疼痛,5眼出现角膜内皮轻微皱褶,2眼中度前房炎症反应,12眼睫状体浅脱离,随访1 mo未出现严重并发症。
结论:小剂量经巩膜二极管激光睫状体光凝术可作为闭角型青光眼急性发作期持续性高眼压患者一种有效的桥接治疗方法,可快速降低眼压、减轻痛苦、挽救视功能,安全性较好,为后续内眼手术降低了风险。
[Key word]
[Abstract]
AIM: To evaluate the safety and efficacy of low-dose transscleral cyclophotocoagulation(TSCP)in the management of persistent ocular hypertension after an acute attack of angle-closure glaucoma(AACG).
METHODS:This retrospective study enrolled patients diagnosed with persistent ocular hypertension after an acute AACG attack at the No.988 Hospital of the Joint Logistics Support Force of the Chinese PLA between September 2023 and September 2024. All patients underwent low-dose TSCP using a semiconductor diode laser. Subsequent cataract surgery combined with goniosynechialysis was performed once intraocular pressure(IOP)was stabilized. Changes in anterior chamber depth(ACD), best-corrected visual acuity(VA), and IOP were compared before and after TSCP, as well as before and after phacoemulsification. Post-TSCP complications were also documented.
RESULTS: A total of 21 patients(21 eyes)were enrolled, including 8 males and 13 females, with a mean age of 67.95±7.25 y. Compared with pre-cyclophotocoagulation values, ACD increased significantly at 3 d post-TSCP(1.49±0.18 vs 1.22±0.21 mm; P<0.001). BCVA and IOP decreased significantly at 1 d post-TSCP, pre-phacoemulsification, 1 wk post-phacoemulsification, and 1 mo post-phacoemulsification compared with pre-TSCP IOP(all P<0.01). Regarding postoperative complications, 2 eyes experienced pain on the day of the procedure, 5 eyes developed mild corneal endothelial folds, 2 eyes exhibited moderate anterior chamber inflammatory reaction, and 12 eyes showed shallow ciliary body detachment. No serious complications occurred during the 1-month follow-up period.
CONCLUSION:Low-dose TSCP appears to be an effective bridging therapy for patients with persistent ocular hypertension following an AACG attack. It facilitates rapid IOP reduction, alleviates symptoms, and helps preserve visual function with a favorable safety profile, thereby reducing the risks associated with subsequent intraocular surgery.
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[基金项目]
河南省医学科技攻关计划联合共建项目(No.LHGJ20240985)