[关键词]
[摘要]
天然黄酮类化合物因其良好的生物安全性和多重药理活性而受到广泛关注。其中，木犀草素(luteolin)作为代表性成分，在多种眼科疾病模型中显示出显著的抗炎、抗氧化、抗血管生成及神经保护作用。其作用机制主要涉及NF-κB、PI3K/Akt、Nrf2/HO-1、AGE-RAGE等关键信号通路的调控。大量实验研究表明，木犀草素在角膜与眼表疾病、炎症性眼病、青光眼、白内障、糖尿病视网膜病变及年龄相关性黄斑变性等多种疾病的防治中具有潜在应用价值。然而，其临床研究仍有限。文章系统综述了近5 a来木犀草素在眼科疾病中的研究进展，分析其分子机制与治疗潜力，并探讨未来的研究方向，为其临床转化提供理论依据。
[Key word]
[Abstract]
Natural flavonoids have attracted considerable attention owing to their favorable biosafety profiles and multiple pharmacological properties in recent years. Luteolin, a representative flavonoid compound, exhibits anti-inflammatory, antioxidant, anti-angiogenic, and neuroprotective effects in multiple ocular disease models by modulating key signaling pathways, including NF-κB, PI3K/Akt, Nrf2/HO-1, and AGE-RAGE. Accumulating experimental evidence supports the potential application of luteolin in various ocular diseases, including corneal and ocular surface diseases, inflammatory eye diseases, glaucoma, cataract, diabetic retinopathy, and age-related macular degeneration. However, clinical evidence remains limited. This review systematically summarizes research progress on luteolin in ocular diseases over the past five years, analyzes its molecular mechanisms and therapeutic potential, and discusses future directions,so as toprovide a theoretical basis for clinical translation.
[中图分类号]
[基金项目]
山东省自然科学基金项目(No.ZR2020MH393); 山东中医药大学临床科研专项(No.LCKY202432)
