[关键词]
[摘要]
干眼与抑郁作为临床常见的慢性疾病，虽在解剖定位和临床表现上看似独立，但其流行病学特征、病理机制及临床转归存在显著交互关联。近年来二者共病现象呈显著上升趋势，但对二者共病机制研究较少。文章系统整理了干眼与抑郁共病的潜在机制，揭示了促炎因子、神经调节、线粒体功能障碍、肠道微生态失衡等分子机制在其中的关键作用，以及睡眠障碍及抗抑郁药物的加剧作用。通过分析现有研究的局限，提供未来研究方向，以期为抑郁与干眼共病的理论研究和临床实践提供新思路。
[Key word]
[Abstract]
Dry eye disease(DED)and depression(DEP), though anatomically and clinically distinct, show significant epidemiological, pathophysiological, and prognostic interplay. Their co-occurrence has risen sharply in recent years, yet the mechanisms driving this comorbidity remain under-investigated. This review systematically synthesizes current evidence, highlighting that pro-inflammatory cytokines, neuro-regulatory imbalance, mitochondrial dysfunction, and gut-microbiota dysbiosis constitute a shared molecular network, while sleep deprivation and antidepressant use further amplify the vicious cycle. By identifying limitations in existing studies, this review proposes future research directions to offer new theoretical and clinical insights for managing DED-DEP comorbidity.
[中图分类号]
[基金项目]
中国中医科学院眼科医院中央高水平医院资助项目(No.GSP2-12)
