目的：探讨高海拔地区配戴角膜塑形镜对近视儿童青少年眼表和睑板腺的影响。

方法：回顾性分析2023年6月至2023年12月在青海爱尔眼科医院就诊并要求配戴角膜塑形镜的近视儿童青少年作为角膜塑形镜组，将同期在本院就诊并配戴普通框架眼镜的近视儿童青少年作为普通框架眼镜组。比较两组患儿戴镜前，戴镜后1、3、6、12 mo眼表疾病指数(OSDI)评分、下泪河高度、非侵入式泪膜破裂时间(NIBUT)\〖首次NIBUT(fNIBUT)、平均NIBUT(avNIBUT)\〗及睑板腺评分。

结果：本研究共纳入近视患儿80例160眼，角膜塑形镜组40例80眼中男25例，女15例，平均年龄11.33±2.76岁，普通框架眼镜组40例80眼中男23例，女17例，平均年龄11.58±2.94岁。两组患儿戴镜前后OSDI评分、下泪河高度比较均无差异(均P>0.05)，戴镜后6、12 mo角膜塑形镜组患儿fNIBUT和avNIBUT较普通框架眼镜组降低，戴镜后12 mo角膜塑形镜组患儿睑板腺评分较普通框架眼镜组升高(均P<0.001)。角膜塑形镜组患儿戴镜后3、6、12 mo fNIBUT、avNIBUT均低于戴镜前(均P<0.05)，角膜塑形镜组戴镜后12 mo睑板腺评分均高于戴镜前，戴镜后1、3、6 mo(均P<0.05)， 普通框架眼镜组戴镜前后f NIBUT、av NIBUT评分及睑板腺评分比较均无差异(均P>0.05)。

结论：高海拔地区近视儿童青少年长期配戴角膜塑形镜可缩短患儿NIBUT，并能对睑板腺功能产生一定影响。

METHODS: Retrospective study. Myopic children and adolescents who visited at the ophthalmology department and received orthokeratology lens from June 2023 to December 2023 were selected as orthokeratology group, and those who visited and wore regular spectacle group during the same period were selected as regular spectacle group. Then the ocular surface disease index(OSDI)score, tear meniscus height, non-invasive breakup time(NIBUT)\〖first NIBUT(fNIBUT), average NIBUT(avNIBUT)\〗, and meibomian gland score were compared between the two groups before wearing lenses, and at 1, 3, 6, and 12 mo after wearing lenses.

RESULTS: A total of 80 children(160 eyes)with myopia were included in this study. Among them, 40 cases(80 eyes)were in the orthokeratology lens group, with 25 males and 15 females and an average age of 11.33±2.76 years old, and 40 cases(80 eyes)were in the regular spectacle group, with 23 males and 17 females and an average age of 11.58±2.94 years old. The OSDI scores and tear meniscus heights showed no clear difference between two groups at various time points before and after wearing glasses(all P>0.05). The fNIBUT and avNIBUT of the orthokeratology lens group decreased compared with the regular spectacle group at 6 and 12 mo after wearing lenses, and meibomian gland score of the orthokeratology group was higher than that of the regular spectacle group at 12 mo after wearing lenses(all P<0.001). Among them, the fNIBUT and avNIBUT of the orthokeratology lenses group at 3, 6, and 12 mo after wearing glasses were lower than those before wearing glasses(all P<0.05). Moreover, the meibomian gland scores of the orthokeratology lenses group at 12 mo after wearing glasses were higher than those before wearing glasses, and 1, 3, and 6 mo after wearing glasses(all P<0.05), while there was no statistical difference in fNIBUT, avNIBUT, and meibomian gland score at each time point in the regular spectacle group(all P>0.05).

CONCLUSION: Long term wearing of orthokeratology lenses can shorten the NIBUT of myopic children and adolescents in high-altitude areas, and have a certain impact on their meibomian gland function.