[关键词]
[摘要]
线粒体相关内质网膜(MAMs)由复杂的蛋白网络构成，作为内质网与线粒体间的关键连接结构，在细胞钙信号稳态、线粒体稳态、内质网应激、免疫炎症反应等方面发挥核心作用。近年来，随着细胞亚显微结构研究技术的发展，MAM功能异常与眼疾病的关联机制逐渐明晰。研究发现，MAM 结构紊乱或功能失调通过干扰视网膜色素上皮细胞稳态、破坏视网膜神经节细胞存活微环境、诱导角膜内皮细胞凋亡等途径，参与年龄相关性黄斑变性、糖尿病视网膜病变、Fuchs 角膜内皮营养不良、青光眼等多种致盲性眼病的病理进程。文章对MAM在常见致盲性眼病的分子关联进行综述。
[Key word]
[Abstract]
Mitochondria-associated endoplasmic reticulum membranes(MAMs)are crucial structural links between the endoplasmic reticulum and mitochondria, formed by a complex protein network. They play a central role in cellular calcium signaling homeostasis, mitochondrial stability, endoplasmic reticulum stress, and inflammatory response. In recent years, advances in subcellular ultrastructure research techniques have gradually uncovered the relationship between MAMs dysfunction and blinding ocular diseases. Studies indicate that structural or functional impairments in MAMs can disrupt retinal pigment epithelial cells homeostasis, compromise the survival microenvironment of retinal ganglion cells, and trigger corneal endothelial cells apoptosis, thereby contributing to the pathogenesis of various blinding ocular diseases including age-related macular degeneration, diabetic retinopathy, Fuchs endothelial corneal dystrophy, and glaucoma. This article reviews the molecular mechanisms linking MAMs in common blinding ocular diseases.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.82171044); 广东省科技专项资金项目(No.2019ST024); 广东省普通高校重点科研平台和项目(No.2022LSYS006,2023KCXTD013)
