目的：评估新型防蓝光膜对改善干眼症状、视功能及视疲劳的临床效能。

方法：本研究为前瞻性研究。于2023年4月至2024年3月期间在宁波市眼科医院招募符合纳入要求的参与者。采用随机数字表法分为新型防蓝光膜组、普防蓝光膜组、无蓝光防护性能透明膜组。干预3 mo，比较干预前后三组参与者泪膜破裂时间(BUT)、调节灵活度、调节幅度及视疲劳评分。

结果：本研究共纳入参与者82例164眼，其中新型防蓝光膜组26例52眼、普通防蓝光膜组26例52眼、无蓝光防护性能透明膜组30例60眼。所有参与者均完成全程研究，无失访。干预3 mo 后，新型防蓝光膜组参与者左眼和右眼BUT较干预前显著延长(均P<0.05)，右眼BUT优于普通防蓝光膜组及无蓝光防护性能透明膜组(均P<0.05)。干预3 mo 后，新型防蓝光膜组右眼调节灵活度及新型防蓝光膜组双眼调节幅度均较干预前提升(P<0.05)； 普通防蓝光膜组双眼调节灵活度均较干预前显著恶化(P<0.05)； 普通防蓝光膜组视疲劳评分较干预前增加(P<0.001)，无蓝光防护性能透明膜组及新型防蓝光膜组视疲劳评分干预前后无显著变化。

结论：新型防蓝光膜可有效延长BUT并改善调节功能，但对视疲劳缓解作用有限； 普通膜加重视疲劳并损害视功能。

METHODS: This study was a prospective trial. From April 2023 to March 2024, participants meeting the inclusion criteria were recruited from Ningbo Eye Hospital. They were randomly divided using a random number table into a novel anti-blue light film group, an ordinary anti-blue light film group, and a transparent film group without blue-light filtering properties. After intervention for 3 mo, tear film break-up time(BUT), accommodative facility, accommodative amplitude, and visual fatigue scores were compared among the three groups before and after the intervention.

RESULTS: A total of 82 participants(164 eyes)were included in this study, comprising 26 participants(52 eyes)in the novel anti-blue light film group, 26 participants(52 eyes)in the ordinary anti-blue light film group, and 30 participants(60 eyes)in the transparent film group without blue-light filtering properties. All participants completed the entire study with no loss to follow-up. After the 3-month intervention, the BUT of both the left and right eyes in the novel anti-blue light film group was significantly prolonged compared to before the intervention(all P<0.05), and the BUT of right eyes was superior to those in both the ordinary anti-blue light film group and the transparent film group without blue-light filtering properties(all P<0.05). After the 3-month intervention, the right eye accommodative facility and the accommodative amplitude of both eyes in the novel anti-blue light film group improved(P<0.05); the accommodative facility of both eyes in the ordinary anti-blue light film group significantly worsened(P<0.05). The visual fatigue score increased in the ordinary anti-blue light film group(P<0.001), while no significant changes were observed before and after intervention in the transparent film group without blue-light filtering properties or the novel anti-blue light film group.

CONCLUSION: The novel anti-blue light film can effectively prolong tear film BUT and improve accommodative function, but its effect on alleviating visual fatigue is limited; the ordinary film exacerbates visual fatigue and impairs visual function.