[关键词]
[摘要]
糖尿病视网膜病变(DR)是糖尿病最常见的微血管并发症之一，其发病机制与免疫炎症反应密切相关。白细胞介素-6(IL-6)作为核心炎症因子，在DR中的作用日益受到关注。IL-6通过经典信号通路发挥神经及血管保护作用，而通过反式信号通路驱动病理过程。其具体机制包括破坏血-视网膜屏障、促进VEGF等炎症因子释放、诱导神经退行性病变及加剧氧化应激。在治疗方面，靶向IL-6的策略多样，包括IL-6/IL-6R拮抗剂、选择性抑制反式信号通路、联合抗VEGF治疗以及基于基因多态性的干预手段。文章将从IL-6的表达调控、作用机制及干预策略三个方面综述其在DR的研究进展。
[Key word]
[Abstract]
Diabetic retinopathy(DR)is one of the most common microvascular complications of diabetes, and its pathogenesis is closely related to immune-inflammatory responses. As a core inflammatory factor, the role of interleukin-6(IL-6)in DR has gained increasing attention. IL-6 exerts neuro- and vaso-protective effects via the classical signaling pathway, while it drives pathological processes primarily through the trans-signaling pathway. The specific mechanisms include disruption of the blood-retinal barrier, promotion of the release of inflammatory factors such as vascular endothelial growth factor(VEGF), induction of neurodegenerative changes, and exacerbation of oxidative stress. Regarding treatment, strategies targeting IL-6 are diverse, including IL-6/IL-6R antagonists, selective inhibition of the trans-signaling pathway, combination therapy with anti-VEGF agents, and interventions based on gene polymorphisms. This review will summarize the research progress on IL-6 in DR from three aspects, including its expression regulation, mechanisms of action, and intervention strategies.
[中图分类号]
[基金项目]
嘉兴市科技计划项目(No.2024AD10004)
