[关键词]
[摘要]
活体共聚焦显微镜(IVCM)作为一种实时、无创的活体成像技术，能够评估眼表组织生理和病理状态下的形态学改变，在细胞层面上更细致、更全面地观察眼表微观世界。近年来，已有大量研究将IVCM引入到球结膜疾病的探索中。通过对细胞特征的高分辨率成像与量化分析，IVCM不仅为揭示球结膜疾病相关机制开拓了新视角，也为临床诊疗及其疗效评估提供了宝贵的纵向数据。因此，文章重点就IVCM在球结膜疾病中应用的研究现状进行综述，同时探讨IVCM在球结膜疾病评估中存在的局限性及其未来临床发展潜力，以期为临床诊疗提供理论参考与实践指引。
[Key word]
[Abstract]
In vivo confocal microscopy(IVCM)is a real-time and non-invasive imaging technology that allows for the evaluation of morphological changes in ocular surface tissues under both physiological and pathological conditions. It offers detailed and cellular-level insight into the microscopic architecture of the ocular surface. In recent years, a growing body of research has incorporated IVCM into the study of bulbar conjunctival diseases. By providing high-resolution imaging and quantitative analysis of cellular features, IVCM not only offers novel insights into the mechanisms underlying these diseases but also supplies valuable longitudinal data for clinical diagnosis, treatment, and therapeutic evaluation. Therefore, this review elucidates the current applications, limitations and future clinical potential of IVCM in bulbar conjunctival diseases, with the aim of providing theoretical reference and practical guidance for clinical practice.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.82171038); 江苏省卫生健康委科研项目(No.M2021084); 江苏省研究生科研与实践创新计划项目(No.SJCX24_2046); 南通市科技项目(No.MS22022020)
