目的：分析全球干眼的研究现状、研究热点及趋势，以期为干眼领域相关研究者提供理论依据及参考，促进该领域的进一步发展。

方法：检索中国知网(CNKI)数据库、万方医学数据库、维普数据库、Web of Science核心合集数据库、PubMed数据库自建库至2025-07-10已发表的干眼相关文献，并通过CiteSpace 6.2.R3和VOSviewer软件对国家/发文机构、研究作者、高频关键词为分析节点进行可视化分析。

结果：目前全球干眼的相关研究已形成各个国家相应的科研团体，发文量位于前3位的国家分别为美国(3 956篇)、中国(2 255篇)、日本(1 053篇)； 全球研究机构发文量最多的是日本的庆应义塾大学(395篇)，其次是美国的哈佛大学(243篇)、哈佛医学院(242篇)； 国内发文量位于前3位的研究机构分别为首都医科大学附属北京同仁医院(83篇)、中山大学中山眼科中心(67篇)、南昌大学第一附属医院(63篇)。中英文高频关键词及爆点关键词分析结果显示：人工智能、强脉冲光治疗、干眼动物疾病模型、病理机制及药物递送为研究热点。

结论：全球干眼临床研究以人工智能诊断技术及强脉冲光治疗为研究热点及趋势； 基础研究以干眼动物模型、氧化应激等病理机制及干眼新型药物研发为热点及趋势。

METHODS: A comprehensive literature search was conducted across the China National Knowledge Infrastructure(CNKI), Wanfang Medical Database, VIP Database, Web of Science Core Collection and PubMed for publications on DED up to July 10, 2025. CiteSpace 6.2.R3 and VOSviewer software were used to perform bibliometric and visualization analyses, focusing on countries/institutions, contributing authors, and high-frequency keywords.

RESULTS: Global research on DED has led to the formation of established scientific communities across various countries. The top three countries in terms of publication volume are the United States(3 956 articles), China(2 255 articles), and Japan(1 053 articles). Among research institutions worldwide, Keio University in Japan ranked first with 395 publications, followed by Harvard University(243 articles)and Harvard Medical School(242 articles)in the United States. In China, the leading institutions are Beijing Tongren Hospital, Capital Medical University(83 articles), Zhongshan Ophthalmic Center, Sun Yat-sen University(67 articles), and the First Affiliated Hospital of Nanchang University(63 articles). Analysis of high-frequency and emerging keywords in both Chinese and English literature identified research hotspots, including artificial intelligence, intense pulsed light(IPL)therapy, animal models of DED, pathophysiological mechanisms, and drug delivery systems.

CONCLUSION: In global DED research, clinical studies are increasingly focused on diagnostic applications of artificial intelligence and therapeutic strategies such as IPL therapy. Basic research trends emphasize pathophysiological mechanisms including oxidative stress and the development of novel pharmacological therapies based on animal models of dry eye disease.