目的：探讨正常眼压性青光眼患者视野缺损的危险因素。

方法：回顾性分析2022年7月至2025年1月本院门诊诊治的164例164眼正常眼压性青光眼患者的病历资料，根据患者视野缺损情况将其分为视野缺损组93眼和无视野缺损组71眼。比较两组临床资料，并采用Logistic回归分析正常眼压性青光眼患者视野缺损的危险因素。

结果：正常眼压性青光眼患者164眼中，有93眼出现视野缺损，发生率为57%。视野缺损组年龄、高度近视人数占比、眼压、眼压波动、阻力指数(RI)均高于无视野缺损组(均P<0.01)，视神经纤维层厚度、视盘血管密度、收缩期血流速度峰值(PSV)、舒张末期血流速度(EDV)均低于无视野缺损组(均P<0.01)。多因素Logistic回归分析显示，高龄(OR=1.171)、高度近视(OR=2.316)、高眼压(OR=1.662)、高眼压波动(OR=1.770)、低视神经纤维层厚度(OR=0.744)、低视盘血管密度(OR=0.547)、低PSV(OR=0.618)、低EDV(OR=0.577)和高RI(OR=1.980)均为正常眼压性青光眼患者视野缺损的危险因素(均P<0.01)。

结论：年龄、高度近视、眼压、眼压波动、视神经纤维层厚度、视盘血管密度、PSV、EDV、RI是正常眼压性青光眼患者视野缺损的影响因素。

METHODS: The general data of 164 patients(164 eyes)with normal tension glaucoma diagnosed and treated in our hospital from July 2022 to January 2025 were retrospectively analyzed. According to the visual field defect, the patients were divided into visual field defect group(93 eyes)and no visual field defect group(71 eyes). The clinical data of the two groups were compared, and the risk factors of visual field defect in patients with normal intraocular pressure glaucoma were analyzed by Logistic regression.

RESULTS: Totally 93 eyes had visual field defect among 164 eyes with normal tension glaucoma, with an incidence rate of 57%. The age, proportion of high myopia, intraocular pressure, intraocular pressure fluctuation and resistance index(RI)in the visual field defect group were higher than those in the non-visual field defect group(all P<0.01), while the retinal nerve fiber layer thickness, the optic disc vascular density, peak systolic blood flow velocity(PSV)and end diastolic blood flow velocity(EDV)in the visual field defect group were lower than those in the non-visual field defect group(all P<0.01). Multivariate Logistic regression showed that advanced age(OR=1.171), high myopia(OR=2.316), ocular hypertension(OR=1.662), high intraocular pressure fluctuation(OR=1.770), low retinal nerve fiber layer thickness(OR=0.744), low optic disc vascular density(OR=0.547), low PSV(OR=0.618), low EDV(OR=0.577)and high RI(OR=1.980)were all risk factors for visual field defect in patients with normal tension glaucoma(all P<0.01).

CONCLUSION: The age, high myopia, intraocular pressure, intraocular pressure fluctuation, retinal nerve fiber layer thickness, optic disc vascular density, PSV, EDV and RI are influence factors for visual field defect in patients with normal tension glaucoma.