[关键词]
[摘要]
基底细胞癌(BCC)是最常见的皮肤癌类型，尤其在眼睑区域的发生率逐年上升，给患者带来了显著的健康负担。Hedgehog(Hh)信号通路在BCC的发生和发展中发挥着关键作用，其异常激活与肿瘤的形成密切相关。因此，Hh信号通路抑制剂作为一种新兴的治疗策略，受到越来越多的关注。文章综述了Hh信号通路抑制剂在眼睑基底细胞癌治疗中的应用，探讨其作用机制、临床效果及未来研究方向。通过对现有文献的分析，总结了Hh信号通路抑制剂在治疗BCC中的潜力，指出了目前临床应用中面临的挑战和亟待解决的问题，期望为未来的研究和临床实践提供参考。
[Key word]
[Abstract]
Basal cell carcinoma(BCC)is the most common type of skin cancer, with an increasing incidence in the eyelid each year, posing a significant health burden on patients. The Hedgehog(Hh)signaling pathway plays a crucial role in the occurrence and development of BCC, with its abnormal activation closely related to tumor formation. Therefore, Hh signaling pathway inhibitors have garnered increasing attention as an emerging therapeutic strategy. This article reviews the application of Hh signaling pathway inhibitors in the treatment of eyelid BCC, exploring their mechanisms of action, clinical effects, and future research directions. Through an analysis of existing literature, the potential of Hh signaling pathway inhibitors in treating BCC was summarized, the challenges faced in current clinical applications were highlighted, and pressing issues that need to be addressed were identified, aiming to provide references for future research and clinical practice.
[中图分类号]
[基金项目]
湖南省自然科学基金项目(No.2024JJ9030); 成都市科学技术局基金项目(No.2024-YF05- 02021-SN); 成都市高新区卫生健康局基金项目(No.2024018)
