[关键词]
[摘要]
视网膜是视觉形成的重要组成部分。视网膜疾病影响正常视觉产生。丝裂原活化蛋白激酶(MAPK)信号通路广泛存在于具有生物活性的细胞中，在细胞生长、增殖、分化及凋亡的生理过程中发挥重要作用。近年研究表明，MAPK信号通路参与视网膜疾病发病机制，如炎症反应、氧化应激、血管异常形成等病理过程。文章旨在总结 MAPK信号通路在视网膜疾病发生发展的调控机制，如糖尿病视网膜疾病、年龄相关性黄斑变性、视网膜静脉阻塞等疾病，并探究对视网膜疾病的潜在治疗靶点，为临床治疗提供新的思路与方法。
[Key word]
[Abstract]
The retina is an important component in the formation of vision. Retinal diseases affect normal vision. The mitogen-activated protein kinase(MAPK)signaling pathway is widely expressed in biologically active cells. The MAPK signaling pathway plays a pivotal role in regulating key physiological processes, including cell growth, proliferation, differentiation and apoptosis. Recent studies have shown that the MAPK signaling pathway is involved in the pathogenesis of retinal diseases, including pathological processes such as inflammatory responses, oxidative stress, and abnormal vascular formation. This article aims to summarize the regulatory mechanism of the MAPK signaling pathway in the occurrence and development of retinal diseases, such as diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and other diseases. Exploring the MAPK pathway's potential as a therapeutic target may provide new insights and strategies for clinical treatment.
[中图分类号]
[基金项目]
内蒙古医学科学院公立医院科研联合基金科技项目(No.2024GLLH0086)
