[关键词]
[摘要]
自身免疫性葡萄膜炎是一种主要由CD4+T细胞介导的免疫失衡引发的致盲性眼内炎症。CD4+T细胞可分化为Th1、Th2、Th17及Treg等多个功能亚群，这些亚群通过分泌细胞因子参与机体的免疫反应，介导炎症的发生与修复。文章核心聚焦于Th1/Th2、Th17/Treg细胞的功能特性、相互作用网络以及它们所分泌的关键细胞因子(如IFN-γ， TNF-α， IL-17， IL-10， TGF-β等)在驱动或抑制眼部炎症过程中的具体效应，目的在于从免疫平衡角度深刻揭示该疾病的发病机制。文章进一步探讨了基于恢复Th1/Th2、Th17/Treg平衡(如调控特定亚群分化、阻断关键促炎因子或增强抑炎功能)的潜在治疗靶点，旨在为优化现有诊疗策略和开发新型免疫疗法(如生物制剂、细胞疗法)提供科学依据和方向指引。
[Key word]
[Abstract]
Autoimmune uveitis is a blinding intraocular inflammation primarily caused by immune dysregulation mediated by CD4+ T cells. CD4+ T cells differentiate into various functional subsets, including Th1, Th2, Th17, and Treg cells. These subsets participate in immune responses and mediate the initiation and resolution of inflammation by secreting different cytokines. This article primarily focuses on the functional characteristics and interplay network of Th1/Th2 and Th17/Treg cells, along with the specific effects of their key secreted cytokines(e.g., IFN-γ, TNF-α, IL-17, IL-10, TGF-β)in driving or suppressing ocular inflammation. The goal is to clarify the fundamental pathogenesis of this disease from the perspective of immune balance. Furthermore, this work explores potential therapeutic targets based on restoring the balance between Th1/Th2 and Th17/Treg, such as modulating the differentiation of specific subsets, blocking key pro-inflammatory cytokines, or enhancing anti-inflammatory functions. This investigation aims to provide a scientific rationale and guidance for optimizing existing diagnostic and therapeutic strategies, as well as developing new immunotherapies(e.g., biological agents, cell therapies).
[中图分类号]
[基金项目]
国家自然科学基金项目(No.82360954)
