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[摘要]
翼状胬肉作为一种常见的眼科疾病,在全球尤其是自然环境恶劣的地区具有较高的发病率,虽然不易致盲,但因其干扰泪膜的正常稳态,常使患者具有眼部干涩、异物感等不适,严重影响患者的生活质量,且翼状胬肉的高手术率占用了大量医疗资源,探索翼状胬肉的发生机制对于该疾病的防控至关重要。目前已有大量研究证明了日光辐射与翼状胬肉发生的相关性,并证实了日光辐射中的紫外线通过直接导致眼表细胞DNA损伤、氧化应激损伤、参与炎症调控和细胞外基质重塑等多种作用机制,促进了翼状胬肉的发生发展。文章总结了翼状胬肉的国内外流行趋势及日光辐射在翼状胬肉发生发展中的多种可能机制,旨在加深对日光与翼状胬肉发生关系的理解,重视并指导临床诊疗中对日光辐射防护意识的宣传。
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[Abstract]
As a common ophthalmic disease, pterygium exhibits a considerably high incidence in global area, particularly in regions with harsh natural environment. While it is unlikely to cause blindness, pterygium frequently disrupts the normal homeostasis of the tear film, leading to discomfort such as dry eyes and foreign body sensation, thereby significantly impairing patients' quality of life. Furthermore, the high surgical intervention rate for pterygium consumes substantial medical resources. Therefore, investigating the underlying mechanisms of pterygium development is essential for its prevention and control. Extensive research has demonstrated the correlation between solar radiation and pterygium occurrence, confirming that ultraviolet rays within solar radiation contribute to the onset and progression of pterygium through multiple pathways, including direct DNA damage to ocular surface cells, oxidative stress-induced injury, involvement in inflammatory regulation, and extracellular matrix remodeling. This paper reviews both domestic and international epidemiological trends of pterygium, as well as the multifaceted mechanisms by which solar radiation influences pterygium development. The aim is to enhance understanding of the relationship between solar exposure and pterygium occurrence, while emphasizing and guiding public awareness of solar radiation protection in clinical practice.
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