[关键词]
[摘要]
眼部特殊的解剖结构和生理屏障对局部药物递送构成了显著挑战，传统眼用制剂的生物利用度普遍低于5%，频繁或大剂量给药不仅增加患者用药负担，还可能引发局部或全身性不良反应。脂质体作为一种新型药物递送系统，凭借其良好的生物相容性和靶向性，在提高眼部药物生物利用度方面展现出显著优势。近年来，通过表面修饰及功能化设计等策略，脂质体制剂在克服眼部屏障、实现可控释放等方面取得了重要进展，在青光眼、干眼等眼部疾病的治疗中展现出良好的应用前景。文章基于近5 a研究进展，重点综述了脂质体在眼部药物递送中的创新设计策略及其应用，以期为眼科新药研发提供理论依据和技术参考。
[Key word]
[Abstract]
The complex anatomical structure and physiological barriers of the eye present substantial challenges for local drug delivery, leading to suboptimal ocular drug bioavailability, which typically remains below 5% in conventional ophthalmic formulations. Frequent or high-dose administration not only increases the treatment burden but also heightens the risk of both local and systemic adverse effects. Liposomes, as an advanced drug delivery system, enhance ocular bioavailability through their biocompatibility and targeted delivery properties. Recent innovations in surface modification and functionalization have further enhanced their ability to overcome ocular barriers and facilitate controlled drug release. Liposome-based formulations have demonstrated significant therapeutic potential for diseases such as glaucoma and dry eye syndrome. Drawing on the research advancements over the past 5 a, this article systematically reviews the innovative design strategies and applications of liposomes in ocular drug delivery, with the aim of providing theoretical basis and technical reference for the development of new ophthalmic drugs.
[中图分类号]
[基金项目]
国家重点研发计划(No.2019YFC1710203); 山东省自然科学基金项目(No.ZR2021LZY045)
