[关键词]
[摘要]
干眼作为多因素所致的慢性眼表疾病，其发病机制与治疗仍面临诸多待突破的挑战。“肠-眼轴”理论的提出，为解析干眼发病机制提供了新视角，也为探索创新防治策略指明了方向。肠道菌群紊乱引发干眼的原因与机制复杂，涉及炎症反应、眼表微生物、眼表神经损伤及菌群代谢产物等方面。文章围绕“肠-眼轴”的免疫代谢调控机制展开综述，梳理以肠道菌群为靶点防治干眼的应用，包括粪便微生物移植、补充益生菌、改善饮食等，以期为干眼的预防与治疗提供理论依据。
[Key word]
[Abstract]
Dry eye disease is a multifactorial chronic ocular surface disorder that is challenging to manage because its pathogenesis is not well understood. The gut-eye axis theory provides insights into its pathogenesis to guide prevention and treatment. Intestinal flora dysbiosis induces dry eye disease through complex mechanisms involving inflammation, ocular surface microbiota, nerve damage, and microbial metabolites. This article reviews the immunometabolic regulation of the gut-eye axis and summarizes gut flora-targeted interventions(fecal microbiota transplantation, probiotic supplementation, and dietary modification)to provide a theoretical basis for dry eye disease prevention and treatment.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.82474638); 江苏省干部保健科研课题项目(No.BJ23012)
