目的：探析自拟知柏地黄方雾化熏蒸治疗阴虚燥热型糖尿病性白内障(DC)术后干眼的临床效果。方法：本研究为前瞻性对照研究，选择本院2022年2月至2024年6月符合纳排标准的阴虚燥热型DC术后干眼患者80例97眼，按照随机数字表法分组，观察组40例49眼，对照组40例48眼。对照组给予玻璃酸钠滴眼液治疗，观察组在对照组基础上联合自拟知柏地黄方雾化熏蒸治疗。对比两组临床疗效、主观症状积分、视觉指标[泪膜破裂时间(BUT)、泪液分泌试验(SⅠt)、角膜荧光素染色(FL)]、泪液炎症因子[白细胞介素-1β(IL-1β)、巨噬细胞趋化蛋白-1(MCP-1)、脂质过氧化物(LPO)]及安全性。结果：观察组好转率96%高于对照组79%(P<0.05)。治疗后两组4项主观症状积分均较治疗前降低，且观察组眼部干涩、异物感、烧灼感、畏光感4项主观症状积分低于对照组(均P<0.05)。治疗后两组BUT、SⅠt均较治疗前升高，FL较治疗前降低，且观察组BUT、SⅠt高于对照组，FL低于对照组(均P<0.05)。治疗后两组IL-1β、MCP-1、LPO均较治疗前降低，且观察组IL-1β、MCP-1、LPO低于对照组(均P<0.05)。两组均未见不良反应发生。结论：自拟知柏地黄方雾化熏蒸治疗阴虚燥热型DC术后干眼患者临床效果显著，可有效降低主观症状积分，改善视觉指标及泪液炎症因子，且安全性较高。

AIM: To explore the clinical effect of atomization fumigation of self-formulated Zhibai Dihuang Decoction in the treatment of dry eye syndrome after diabetic cataract(DC)surgery with Yin deficiency and dry heat pattern.METHODS: This study is a prospective controlled study. From February 2022 to June 2024, 80 patients(97 eyes)with Yin deficiency and dry heat type DC postoperative dry eye who met the inclusion and exclusion criteria in our hospital were selected. They were randomly divided into an observation group of 40 cases(49 eyes)and a control group of 40 cases(48 eyes)using a random number table method. The control group was treated with sodium hyaluronate eye drops, while the observation group was treated with a combination of atomization fumigation of self-formulated Zhibai Dihuang Decoction on the basis of the control group. The clinical efficacy, subjective symptom scores, visual indicators [tear film break-up time(BUT), Schirmer's test(SIt), corneal fluorescein staining(FL)], tear inflammatory factors [interleukin-1 β(IL-1β), macrophage chemoattractant protein-1(MCP-1), lipid peroxidation(LPO)], and safety between the two groups.RESULTS: The improvement rate of the observation group was 96%, which was higher than that of the control group(79%, P<0.05). After treatment, the 4 subjective symptom scores in both groups were lower than those before treatment, and the subjective symptom scores of ocular dryness, foreign body sensation, burning sensation, and photophobia in the observation group were lower than those in the control group(all P<0.05). After treatment, BUT and SIt in both groups were higher than those before treatment, and FL was lower than that before treatment, with the observation group having higher BUT and SIt and lower FL than the control group(all P<0.05). After treatment, IL-1β, MCP-1, and LPO in both groups were lower than those before treatment, and the observation group had lower levels of IL-1β, MCP-1, and LPO than the control group(all P<0.05). No adverse reactions were observed in either group.CONCLUSION: The atomization and fumigation of self-formulated Zhibai Dihuang Decoction is significantly effective in treating dry eye syndrome after DC surgery with Yin deficiency and dry heat pattern. It can effectively reduce subjective symptom scores, improve visual indicators and tear inflammatory factors, and has a high level of safety.