目的：探究年龄相关性白内障(ARC)患者晶状体上皮细胞中微小RNA-34a(miR-34a)、微小RNA-29b(miR-29b)水平变化及临床意义。方法：选取本院2023年2月至2024年2月就诊的65例ARC患者(研究组)与53例透明晶状体前囊膜(对照组)。Pearson分析miR-34a与miR-29b的相关性，多因素Logistic回归分析影响ARC发生的因素。结果：与对照组相比，研究组晶状体上皮细胞中miR-34a、miR-29b表达水平都呈现明显降低的趋势(均P<0.05)。ARC患者晶状体上皮细胞中miR-34a与miR-29b呈正相关(r=0.472，P<0.05)。miR-34a、miR-29b是ARC的影响因素(均P<0.05)。结论：ARC患者晶状体上皮细胞中miR-34a、miR-29b水平显著降低，与ARC的发生有关。

AIM: To investigate the changes of microRNA-34a(miR-34a)and microRNA-29b(miR-29b)levels in lens epithelial cells of age-related cataracts(ARC)patients and their clinical significance.METHODS: A total of 65 ARC patients(study group)and 53 cases of clear lens anterior capsulorhexis(control group)who visited our hospital from February 2023 to February 2024 were gathered. Pearson was applied to test the correlation between miR-34a and miR-29b. Multifactor Logistic regression was applied to determine the factors affecting the occurrence of ARC.RESULTS: Compared with the control group, the expression levels of miR-34a and miR-29b in lens epithelial cells of the research group showed a significant decrease trend(all P<0.05). There was a positive correlation between miR-34a and miR-29b in the lens epithelial cells of ARC patients(r=0.472, P<0.05). MiR-34a and miR-29b were influence factors for ARC(all P<0.05).CONCLUSION: The levels of miR-34a and miR-29b in lens epithelial cells of ARC patients are significantly reduced, which is associated with the occurrence of ARC.