目的：探究2型糖尿病(T2DM)患者血清高敏C反应蛋白(hsCRP)在糖尿病视网膜病变(DR)发生发展中的作用。方法：选取2017年6月至2024年10月于首都医科大学附属北京同仁医院眼科中心就诊的T2DM患者187例187眼，进行巢式病例对照研究。将T2DM患者进一步分为糖尿病(DM)组、非增殖性糖尿病视网膜病变(NPDR)组和增殖性糖尿病视网膜病变(PDR)组。收集患者的一般临床资料(包括年龄、性别、DM病程、高血压病程)，行空腹生化检查及眼科检查。结果：Spearman相关分析结果显示，hsCRP与空腹血糖(FBG)(P=0.004)、糖化血红蛋白(HbA1c)(P=0.048)呈正相关。控制混杂因素后，多因素Logistic回归模型显示hsCRP(OR=2.67，95%CI：1.19-5.96，P=0.017)是DR发生发展的危险因素。结论：血清hsCRP与FBG及HbA1c呈正相关，可作为DR严重程度的预测因子。

AIM:To investigate the role of serum high-sensitivity C-reactive protein(hsCRP)in the pathogenesis and progression of diabetic retinopathy(DR)in patients with type 2 diabetes mellitus(T2DM).METHODS:A nested case-control study was conducted involving 187 T2DM patients(187 eyes)who attended at Eye Center, Beijing Tongren Hospital, Capital Medical University from June 2017 to October 2024. Patients were categorized into three groups: the diabetes mellitus(DM)group, non-proliferative DR(NPDR)group, and proliferative DR(PDR)group. Baseline information was collected, including age, sex, duration of DM, and duration of hypertension. All patients underwent fasting biochemical tests and comprehensive ophthalmic examinations.RESULTS: A positive correlation was observed between hsCRP and fasting blood glucose(FBG; P=0.004)and glycated hemoglobin A1c(HbA1c; P=0.048)by Spearman's rank correlation coefficient analysis. After adjusting for confounding factors, multivariable Logistic regression identified hsCRP as a significant risk factor for DR(OR=2.67, 95% CI: 1.19-5.96, P=0.017). CONCLUSION:Serum hsCRP is positively correlated with FBG and HbA1c and can serve as an important predictor of the severity of DR.

国家自然科学基金(No.82070988); “十四五”国家重点研发计划政府间国际科技创新合作重点专项(No.2024YFE0100900); 国家科技重大专项项目(No.2023ZD05090002)