目的：探讨3%地夸磷索钠滴眼液对配戴夜戴型角膜塑形镜患者泪膜稳态的影响。方法：回顾性研究。选取2022年6月至2022年12月在我院戴夜戴型角膜塑形镜患者340例564眼，根据使用药物不同分为3%地夸磷索钠滴眼液组200例323眼，玻璃酸钠滴眼液组140例241眼。比较两组患者戴镜前，戴镜1 wk，1、3 mo后裸眼视力(LogMAR)、眼表疾病指数量表(OSDI)评分、非侵入性泪膜破裂时间(NIBUT)、睑板腺红外成像评分、角膜上皮荧光素的染色情况及不良反应。结果：两组患者戴镜1 wk，1、3 mo后裸眼视力(LogMAR)较戴镜前比较均有差异(均P<0.01)，而两组间戴镜前后裸眼视力(LogMAR)比较均无差异(均P>0.05)。戴镜前和戴镜1 wk后两组患者的NIBUT及OSDI评分均无差异(均P>0.05)，戴镜1、3 mo后，3%地夸磷索钠滴眼液组患者NIBUT均明显高于玻璃酸钠滴眼液组(均P<0.001)，OSDI评分均明显低于玻璃酸钠滴眼液组(均P<0.001)； 戴镜3 mo后，3%地夸磷索钠滴眼液组患者睑板腺红外成像评分优于玻璃酸钠滴眼液组(P<0.001)，而两组角膜荧光素染色情况比较无差异(P>0.05)。两组患者戴镜期间不良事件发生情况比较无差异(P>0.05)。结论：与玻璃酸钠滴眼液相比，3%地夸磷索钠滴眼液对配戴夜戴型角膜塑形镜患者具有较好的维持泪膜稳态的功效。

AIM:To investigate the effect of 3% diquafosol sodium eye drops on tear film homeostasis in patients wearing overnight orthokeratology lenses.METHODS:Retrospective study. A total of 340 patients(564 eyes)fitted with night-worn orthokeratology lenses from June to December 2022 were respectively divided into a diquafosol sodium group(200 cases, 323 eyes, treated with 3% diquafosol sodium eye drops)and a sodium hyaluronate group(140 cases, 241 eyes, treated with sodium hyaluronate eye drops). The uncorrected visual acuity(LogMAR), ocular surface disease index(OSDI), non-invasive tear film break-up time(NIBUT), meibomian gland infrared imaging score, and corneal epithelial fluorescein staining were analyzed and compared between the two groups.RESULTS:Compared to baseline, both groups showed significant improvements in uncorrected visual acuity(LogMAR)at 1 wk, 1, and 3 mo after lens wear(all P<0.01). However, no statistically significant difference in uncorrected visual acuity(LogMAR)was observed between the two groups at any time point(all P>0.05). No significant differences in NIBUT or OSDI scores were found between the groups before and at 1 wk after lens wear(all P>0.05). At the 1- and 3 mo follow-ups, the 3% diquafosol sodium group demonstrated significantly longer NIBUT(all P<0.001)and lower OSDI scores(all P<0.001)compared to the sodium hyaluronate group. After wearing lens for 3 mo, the meibomian gland infrared imaging scores were significantly better in the diquafosol sodium group(P<0.001), whereas no significant intergroup difference was observed in corneal fluorescein staining(P>0.05). Furthermore, the incidence of adverse events during the study period did not differ significantly between the two groups(P>0.05).CONCLUSION:Compared with sodium hyaluronate, 3% diquafosol sodium eye drops were more effective in maintaining tear film homeostasis in patients wearing overnight orthokeratology lenses.