目的：比较折叠式球囊(FCB)巩膜外加压术和传统巩膜扣带术(SB)治疗实验性视网膜脱离模型的疗效。方法：成功建立孔源性视网膜脱离(RRD)动物模型后，将24只新西兰大白兔随机分为3组(RRD模型组、SB组、FCB组)，每组8只。SB组和FCB组对造模成功的RRD动物模型进行SB和FCB巩膜外加压术，RRD模型组只建立RRD动物模型，观察期内不进行任何手术操作，术后观察期为3 mo。采用新生儿广域眼底成像系统和眼科B超评估手术前后眼底情况，采用眼压计Icare&#xAE； TONOVET Plus评估手术前后眼压变化情况，采用Eaton和Draize评分评估术后炎症反应情况。结果：FCB组和SB组术后视网膜的复位率分别为87.5%和75.0%，组间无差异(P>0.05)。FCB组和SB组术后眼压均较术前上升(P<0.01)，且观察期各时间点的眼压均无组间差异(P>0.05)。RRD模型组的眼压在观察期均保持较低的状态。FCB组的平均手术时间为16.87±2.29 min短于SB组的平均手术时间46.25±4.74 min(t= -15.166，P<0.001)。根据Eaton和Draize评分系统显示，FCB组术后早期结膜充血分级及结膜水肿分级均低于SB组，炎症反应更轻(P<0.05)。结论：FCB巩膜外加压术和SB均能有效治疗实验性RRD。与SB相比，FCB巩膜外加压术操作简单、手术时间短，显著降低手术创伤及炎症风险。

AIM: To compare the effectiveness of foldable capsular body(FCB)with traditional scleral buckling(SB)in the treatment of experimental retinal detachment animal models.METHODS: After successfully establishing rhegmatogenous retinal detachment(RRD)animal models, 24 New Zealand white rabbits were randomly divided into three groups(RRD models group, SB group, and FCB group), with 8 rabbits in each group. The FCB and SB groups underwent SB and FCB surgeries for the RRD animal models, while the RRD models group only consists of RRD models without any surgical intervention during the follow-up period. The follow-up duration was 3 mo. Wide-field neonatal fundus imaging system and ophthalmic B-ultrasound were used to assess the fundus conditions before and after surgery. The Icare&#xAE; TONOVET Plus tonometer was utilized to evaluate intraocular pressure changes before and after surgery. The Eaton and Draize scoring systems were selected to monitor postoperative inflammatory reactions.RESULTS: The retinal reattachment rates in the FCB and SB groups were 87.5% and 75.0%, respectively, with no statistically significant difference between the groups(P>0.05). The intraocular pressure in both the FCB and SB groups increased postoperatively compared to preoperative levels(P<0.01), and there were no significant differences in intraocular pressure at any time points during the follow-up period between the groups(P>0.05). The intraocular pressure in the RRD models group remained at a low level throughout the follow-up period. The average surgical time for the FCB group was 16.87±2.29 min, which was shorter than 46.25±4.74 min in the SB group(t=-15.166, P<0.001). According to the Eaton and Draize scoring systems, the FCB group had lower grades of conjunctival hyperemia and edema in the early postoperative period compared to the SB group, indicating milder inflammatory reactions(P<0.05).CONCLUSION: Both FCB and SB are effective in treating experimental RRD. Compared to SB, FCB is simpler to operate, and also has a shorter surgical time and milder postoperative inflammatory reactions.

河南省自然科学基金项目(No. 202300420066)