[关键词]
[摘要]
再生医学是融合分子和细胞生物学、基因编辑、生物材料与生物工程学等方法激活自身潜能,替代、修复或再生受损组织器官的新兴交叉学科。眼科学是其中最活跃和具有巨大前景的领域,受到全球范围内各国政府和研究机构的高度重视。其进展代表了医学和眼科研究的最前沿方面。目前眼科再生医学的治疗对象包括眼表及角膜病,视网膜疾病如糖尿病视网膜病变、年龄相关性黄斑变性、遗传性视网膜疾病,青光眼等眼科不可逆疾病。一些临床前或临床试验已显示令人鼓舞的结果。再生医学的挑战包括伦理学、细胞输送、长期效果与安全性等。在此简要介绍相关概念、研究现状和进展,并期待国内眼科再生医学研究不断取得新成果。
[Key word]
[Abstract]
Regenerative medicine(RM)is an emerging interdisciplinary field that integrates molecular and cellular biology, gene editing, biomaterials and bioengineering to activate one's own potential, replace, repair or regenerate damaged tissues and organs. Ophthalmology is one of the most active and promising fields in RM, and is highly valued by governments and research institutions around the world. Its progress represents the most cutting-edge aspects of medical and ophthalmic research. Currently, the treatment targets of ophthalmic RM include ocular surface and corneal diseases, retinal diseases such as diabetic retinopathy, age-related macular degeneration, inherited retinal diseases, glaucoma and other irreversible ophthalmic disorders. Some preclinical or clinical trials have shown encouraging results. The challenges for RM include ethics, cell delivery, long-term efficacy and safety, etc. We herein briefly introduce the relevant concepts, research status and progress, and look forward to continuous new achievements in domestic RM.
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[基金项目]