目的：探讨外周血相关炎性指标对糖尿病视网膜病变(DR)患者继发新生血管性青光眼(NVG)的影响。方法：回顾性病例对照研究。根据患者有无NVG分为两组：单纯增殖性糖尿病视网膜病变(PDR)患者(单纯PDR组，148例)和继发于PDR的NVG患者(PDR继发NVG组，142例)，记录两组患者的外周血炎性指标水平，包括白细胞相关炎症指标、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值、单核细胞与淋巴细胞比值以及全身免疫炎症指数，分析两组患者外周血炎性指标的差异及与PDR继发NVG的关系。结果：两组患者基本特征无差异，具有可比性。单纯PDR组与PDR继发NVG组患者嗜酸性粒细胞百分比、单核细胞与淋巴细胞比值存在差异(均P<0.05)，PDR继发NVG组明显高于单纯PDR组患者。多因素Logistic回归分析显示，嗜酸性粒细胞百分比、单核细胞与淋巴细胞比值是PDR患者继发NVG的影响因素。结论：嗜酸性粒细胞百分比、单核细胞与淋巴细胞比值可能与PDR进展为NVG有关，可能对PDR患者继发NVG有预测作用。

AIM: To investigate the influence of relevant inflammatory markers in peripheral blood on the progression of neovascular glaucoma(NVG)secondary to diabetic retinopathy(DR)patients.METHODS: Retrospective case-control study. Patients were categorized into two groups based on the presence or absence of NVG: those with proliferative diabetic retinopathy(PDR)alone(PDR group, n=148)and those with NVG secondary to PDR(NVG secondary to PDR group, n=142). Peripheral blood inflammatory markers were evaluated, including white blood cell-related indices, neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), monocyte-to-lymphocyte ratio(MLR), and systemic immune-inflammation index(SII). The distinctions in peripheral blood inflammatory markers between the two groups of patients and their relationships with NVG secondary to PDR were analyzed.RESULTS:No statistically significant differences were observed in basic characteristics between the two groups, confirming their comparability. However, significant differences were found in eosinophil percentage and MLR between the PDR group and the NVG secondary to PDR group(all P<0.05), with both values being significantly higher in the NVG secondary to PDR group. Multivariate Logistic regression analysis revealed that the eosinophil percentage and the MLR were factors influencing the development of patients with NVG secondary to PDR.CONCLUSION: Eosinophil percentage and MLR may be associated with the progression of PDR to NVG, and could serve as potential predictive markers for NVG development in PDR patients.

山东省自然科学基金面上项目(No.ZR2023MH069); 潍坊医学院附属医院医学研究培育基金项目(No.2022wyfyzzjj10)