目的：观察学龄儿童的脉络膜血管指数(CVI)基础日节律幅度与年等效球镜度数(SE)及年眼轴变化量的相关性。

方法：前瞻性研究。选取2021-07/08在温州医科大学附属眼视光医院视光门诊诊断为正视和近视屈光不正的7-12岁汉族学龄儿童共39例39眼，其中有6例未完成1 a随访，最终纳入33例33眼，将SE年增长量<0.5 D分为非进展组16例16眼， SE年增长量≥0.5 D分为进展组17例17眼。使用扫频源光学断层扫描技术和脉络膜量化分析软件，纵向观察参与者的CVI日节律幅度，并分析其与SE及眼轴年变化量的相关性。

结果：非进展组脉络膜黄斑中心凹1 mm处CVI日节律幅度与SE年变化量无显著相关性(P=0.65)，而进展组脉络膜黄斑中心凹1 mm处CVI日节律幅度与SE年变化量呈负相关性(P=0.048)，两组CVI日节律幅度与眼轴年变化量无相关性(均P>0.05)。进展组脉络膜黄斑中心凹1 mm处CVI日节律幅度是SE年变化量的影响因素(P=0.039)，而眼轴的日节律幅度及眼轴年变化量、CVI日最大值时间(峰时)，日最小值时间(谷时)对SE年进展影响不显著(均P>0.05)。

结论：学龄儿童的CVI日节律幅度与SE进展具有一定相关性，为进一步理解近视发生发展过程中的脉络膜相关的变化机制提供一定的依据。

METHODS: Prospective study. Totally 39 cases(39 eyes)of Chinese school-age children aged 7 to 12 that diagnosed as emmetropia and myopia and error of refraction at optometry clinics of Eye Hospital, Wenzhou Medical University from July to August 2021 were selected. While 33 cases(33 eyes)were finally included, with 6 cases of loss to 1 a follow-up. A total of 16 cases(16 eyes)with annual growth of SE<0.5 D and 17 cases(17 eyes)with annual growth of SE≥0.5 D were divided into a non-progression group and progression group, respectively. Swept-source optical coherence tomography(SS-OCT)and custom choroidal analysis software were used to longitudinally observe diurnal variations in CVI of subjects, and the association between CVI diurnal amplitude and annual changes in SE and axial length was analyzed.

RESULTS:It showed no significant correlation between the CVI diurnal amplitude at 1 mm from the fovea and annual changes in SE of the non-progressive group(P=0.65), while in the progression group, the CVI diurnal amplitude at 1 mm from the fovea was negatively correlated with annual changes in SE(P=0.048). However, no significant correlation was identified between CVI diurnal amplitude and annual changes in axial length in either group(all P>0.05). The diurnal amplitude of the CVI at the 1 mm foveal center had an effect on annual SE progression(P=0.039). Conversely, the diurnal amplitude of axial length, the annual changes in axial length, and the maximum or minimum time of CVI demonstrated significant associations with SE progression(all P> 0.05).

CONCLUSION: Diurnal variations in CVI amplitude are associated with SE progression in school-aged children, providing a basis for further understanding the choroid-related changes in the process of myopia onset and progression.