目的：探究地夸磷索钠滴眼液联合玻璃酸钠滴眼液治疗白内障术后干眼的疗效。

方法：前瞻性随机对照研究。选取2022-11/2024-10我院眼科收治的白内障术后干眼患者360例360眼。将患者随机分为两组：对照组180眼给予玻璃酸钠滴眼液治疗； 观察组180眼给予地夸磷索钠滴眼液联合玻璃酸钠滴眼液治疗。两组患者均治疗4 wk。比较两组患者临床疗效，治疗前后干眼临床症状评分及眼表疾病指数(OSDI)问卷、泪液分泌试验(SⅠt)、泪膜破裂时间(BUT)、角膜荧光素染色(FL)评分、六角形细胞比例(HEX)及角膜内皮细胞变异系数(CV)，并记录两组患者治疗期间不良反应发生情况。

结果：所有患者均完成随访，无失访病例。观察组临床总有效率为93.9%，高于对照组84.5%(P<0.05)。治疗4 wk，两组患者干眼临床症状评分和OSDI评分及FL评分均下降，且观察组均低于对照组(均P<0.001)； 两组患者SⅠt及BUT均上升，且观察组均高于对照组(均P<0.001)。治疗4 wk，两组HEX均上升(P<0.05)，且观察组更高(P<0.05)； 两组CV均下降(P<0.05)，且观察组更低(P<0.05)。两组患者不良反应发生率比较无差异(P>0.05)。

结论：相较于单纯使用玻璃酸钠滴眼液治疗白内障术后干眼，给予地夸磷索钠滴眼液联合玻璃酸钠滴眼液治疗疗效更佳，可显著改善患者眼部症状，促进眼表功能恢复及泪膜稳定，调节角膜内皮细胞状态。

METHODS:This study is a prospective randomized controlled study. Totally 360 patients(360 eyes)with dry eye syndrome after cataract surgery admitted to the ophthalmology department of our hospital from November 2022 to October 2024 were selected as the research subjects, and they were randomly divided into a control group(n=180)and an observation group(n=180). The control group received postoperative treatment with sodium hyaluronate eye drops, while the observation group received postoperative treatment with diquafosol sodium eye drops combined with sodium hyaluronate eye drops. Both groups of patients were treated for 4 wk. The clinical efficacy, dry eye clinical symptom score and ocular surface disease index(OSDI)questionnaire, Schirmer's test(SⅠt), tear film break-up time(BUT), corneal fluorescence staining(FL)score, hexagonality(HEX), coefficient of variation(CV)of corneal endothelial cells were compared between the two groups before and after treatment, and the occurrence of adverse reactions during treatment in both groups was recorded.

RESULTS:Both groups were followed up for 4 wk, and no cases were lost. The total clinical effective rate of the observation group was 93.9%, which was higher than 84.5% of the control group(P<0.05). After treatment for 4 wk, the clinical symptom score, OSDI scores and FL scores in both groups decreased, and the observation group had lower scores than those of the control group(all P<0.001); both SⅠt and BUT increased in both groups, and the observation group had a higher value than those of the control group(all P<0.001). After treatment for 4 wk, the HEX in both groups increased(P<0.05), and those in the observation group were higher(P<0.05); the CV of the two groups decreased(P<0.05), and the observation group was lower(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).

CONCLUSION:Compared to sodium hyaluronate eye drops alone, diquafosol sodium eye drops combined with sodium hyaluronate eye drops have a better therapeutic effect on patients with dry eye syndrome after cataract surgery. It can significantly improve the patient's eye symptoms, promote the recovery of eye surface function, stabilize the tear film, and regulate corneal endothelial cell status.