Glaucoma is a neurodegenerative disorder primarily characterized by the degeneration of retinal ganglion cells(RGCs). This condition can arise from a complex interplay of multiple mechanisms, including elevated intraocular pressure(IOP), neurotrophic factor deprivation, immune-mediated responses, oxidative stress, and excitotoxicity. Due to the absence of significant clinical symptoms in its initial stages, individuals often remain unaware of the disease until they experience irreversible vision loss, highlighting the critical importance of early diagnosis. Current diagnostic methods predominantly focus on measuring elevated IOP, assessing characteristic visual field deficits, and examining fundoscopic changes in the optic disc. Unfortunately, these indicators typically manifest only after considerable optic nerve damage has already occurred. Consequently, the identification of biomarkers associated with RGCs loss is essential for enhancing the early diagnosis and management of glaucoma. This study aims to investigate the molecular mechanisms underlying RGCs degeneration and to determine the potential existence of biomarkers within these pathways. By identifying early alterations in these biomarkers, we hope to facilitate timely intervention strategies for glaucoma, ultimately reducing the risk of vision loss and improving the overall quality of life for affected individuals.

南京医科大学科技发展基金项目(No.NMUB20230247)