[关键词]
[摘要]
角膜碱烧伤是一种常见的角膜外伤，其治疗一直是眼科领域的难题。传统治疗方法包括抗炎、免疫抑制和角膜移植等，但效果有限。本综述聚焦于间充质干细胞(MSCs)及其来源的细胞外囊泡(MSCs-EVs)在角膜碱烧伤治疗中的研究进展。MSCs具有自我更新、多向分化和免疫调节能力，而MSCs-EVs继承了MSCs的功能，且具有更低的免疫原性和更好的生物相容性，为眼科治疗提供了新途径。此外，生物支架因其优异的生物相容性和可降解性，在组织工程中作为支架或药物递送系统，促进组织再生。文章综述了MSCs-EVs联合生物支架在角膜碱烧伤治疗中的作用机制和研究进展，探讨了其在促进角膜碱烧伤的修复和改善视力方面的潜力。这些发现为角膜碱烧伤的治疗提供了新的策略，有望改善患者的预后。
[Key word]
[Abstract]
Corneal alkali burns are a common form of corneal trauma, and their treatment has been a challenge in ophthalmology. Traditional treatments include anti-inflammatory, immunosuppressive, and corneal transplantation, with limited results. This review focuses on the research progress of mesenchymal stem cells(MSCs)and their derived extracellular vesicles(MSCs-EVs)in the treatment of corneal alkali burns. MSCs have the ability of self-renewal, multidirectional differentiation, and immunomodulation, and the MSCs-EVs inherit its function from MSCs. MSCs-EVs inherit the functions of MSCs and has lower immunogenicity and better biocompatibility, which provides a new avenue for ophthalmic treatment. In addition, bioscaffolds are used as scaffolds or drug delivery systems in tissue engineering to promote tissue regeneration due to their excellent biocompatibility and degradability. This article reviews the mechanism of action and research progress of MSCs-EVs and combined bioscaffolds in the treatment of corneal alkali burns, and explores their potential in promoting the repair of corneal alkali burns and improving vision. These findings provide new strategies for the treatment of corneal alkali burns and are expected to improve the prognosis of patients.
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[基金项目]
新疆维吾尔自治区自然科学基金资助项目(No.2024D01A100); 乌鲁木齐市卫生健康委员会科技计划项目(No.202461); 新疆四七四医院院内项目(No.2023xj474001); 新疆军区总医院北京路医疗区重点扶持科研项目(No.2022jzbjl18)
