[关键词]
[摘要]
白内障是由于晶状体代谢紊乱引起的常见眼科疾病，可导致视力障碍或失明，其发生发展受多种因素影响，其中年龄是最主要的因素。目前药物治疗仅针对早期白内障有延缓作用，但对于发展到中晚期影响视力的白内障仍需手术治疗。因此建立实验性白内障模型，探索合适的药物预防和治疗白内障至关重要。D-半乳糖已广泛应用于衰老动物模型研究，常被用于糖尿病性白内障和年龄相关性白内障的模型。文章对D-半乳糖诱导白内障模型的发病机制、造模方法以及造模成功的评定标准进行阐述，以期指导白内障防治相关的实验性研究。
[Key word]
[Abstract]
Cataract is a common eye disease caused by metabolic disorders of the lens, which can lead to visual impairment or blindness. Its occurrence and development are affected by various factors, among which age is the most important factor. At present, drug therapy only has a delaying effect on early cataracts, but surgical treatment is still needed for cataracts that affect vision in the middle and late stages. Therefore, it is crucial to establish an experimental cataract model and explore appropriate drugs for preventing and treating cataracts. D-galactose has been widely used in the study of aging animal models, and is often used in the models of diabetes cataract and age-related cataract. This article elaborates on the pathogenesis, modeling methods, and evaluation criteria for successful modeling of D-galactose-induced cataract models, in order to guide experimental researches related to cataract prevention and treatment.
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[基金项目]
国家自然科学基金项目(No. 82074495); 上海市普陀区中心医院匠才计划项目(No. 2022-RCJC-06); 上海市东方英才计划拔尖项目
