[关键词]
[摘要]
糖尿病视网膜病变(DR)是糖尿病的主要并发症之一，以神经退行性病变和微血管病变为其主要特征。目前，DR的治疗主要关注于晚期并发症的处理，没有达到理想的临床疗效。证据表明，PI3K/AKT通路作为细胞周期过程中重要的胞内信号通路之一，参与了DR发病的全过程。文章主要从PI3K/AKT信号通路的结构组成、激活和阻止途径、传导路径、调控机制和生物学功能等方面，综述其在DR中的作用，并探讨靶向PI3K/AKT通路治疗DR的潜力。
[Key word]
[Abstract]
Diabetic retinopathy(DR)is one of the major complications of diabetes mellitus, characterized by neurodegeneration and microangiopathy. Currently, the treatment of DR is mainly focused on the management of late complications and has not achieved the desired clinical outcome. Evidence suggests that the PI3K/AKT pathway, as one of the important intracellular signaling pathways during the cell cycle, is involved in the whole process of DR pathogenesis. This article focuses on the structural composition, activation and blocking pathways, conduction pathways, regulatory mechanisms and biological functions of the PI3K/AKT signaling pathway to review its role in DR and to explore the potential of targeting the PI3K/AKT pathway for the treatment of DR.
[中图分类号]
[基金项目]
中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者{No.国中医药人教发\〖2018\〗284号}; 福建省第三批柔性引进医疗卫生高层次人才团队; 北京市石景山区亢泽峰名医传承工作室项目
