残余胆固醇与前部缺血性视神经病变的相关性分析

Correlation between remnant cholesterol and anterior ischemic optic neuropathy

摘要:

目的：探讨残余胆固醇(RC)与前部缺血性视神经病变(AION)的相关性。

方法：选取2020-01/2023-12于临沂市人民医院眼科住院治疗的AION患者80例作为观察组，选择同期于临沂市人民医院完成健康体检者(未发生缺血性视神经病变及其他眼底血管病变)80例作为对照组。比较两组患者一般资料及生化指标，评价RC与AION的相关性。

结果：与对照组比较，AION患者残余胆固醇(RC)、空腹血糖(FBG)、总甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平明显高于对照组(均P<0.01)。Spearman相关分析显示，RC与TG、TC、LDL-C呈正相关(均P<0.01)。Logistic回归分析表明，RC、FBG是AION发病的危险因素。受试者工作特征(ROC)曲线分析表明，与FBG相比，RC水平对于AION的发生具有更好的预测价值。

结论：RC与AION的发生相关，是AION发病的危险因素，临床上对于RC水平高的人群进行规范化管理，可降低AION的发病风险，这对预防AION的发生具有一定临床意义。

Abstract:

AIM: To explore the correlation between remnant cholesterol(RC)and anterior ischemic optic neuropathy(AION).

METHODS: A total of 80 cases of AION patients hospitalized in the department of ophthalmology of Linyi People's Hospital from January 2020 to December 2023 were selected as the observation group, and 80 cases of those who had completed health checkups in Linyi People's Hospital during the same period(without ischemic optic neuropathy and other fundus vasculopathies)were selected as the control group. The general data and biochemical indexes of the two groups were compared to evaluate the correlation between RC and AION.

RESULTS: Compared with the control group, the levels of RC, fasting blood glucose(FBG), triglyceride(TG), total cholesterol(TC), and low-density lipoprotein cholesterol(LDL-C)in patients with AION were significantly higher than those in the control group(all P<0.01). Spearman correlation analysis showed that RC was positively correlated with TG, TC, and LDL-C(all P<0.01). Logistic regression analysis showed that RC and FBG were risk factors for the development of AION. The analysis of receiver operating characteristic(ROC)curves showed that the level of RC had a better predictive value for the development of AION compared with FBG.

CONCLUSION: RC is associated with the development of AION and is a risk factor for the development of AION. Clinical standardization of the management of people with high RC values can reduce the risk of the development of AION, which is of clinical significance.