SPT辅助的TPRK术后角膜上皮厚度和光密度的变化及两者的相关性
CSTR:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

新乡市科技攻关计划项目(No.GG2021030)


Changes in corneal epithelial thickness and optical density and their correlation after smart pulse technology-assisted transepithelial photorefractive keratectomy
Author:
Affiliation:

Fund Project:

Xinxiang Science and Technology Tackling Program Projects(No.GG2021030)

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察智能脉冲技术(SPT)辅助的经上皮准分子激光角膜切削术(TPRK)术后角膜上皮厚度(CET)和光密度(CD)变化,并分析两者的相关性。

    方法:前瞻性研究。选取2023-02/08在新乡医学院第一附属医院眼科行SPT-TPRK手术治疗的近视及近视散光患者60例120眼,评估术前、术后1 wk,1、3 mo CET与CD的变化。

    结果:纳入患者失访14例28眼,术后出现haze 3例6眼,均剔除本研究,最终纳入患者43例86眼。术后1 wk,CET高于术前(P<0.05),角膜中央0-2 mm区域CET明显增厚(P<0.05); 术后1 mo,角膜中央0-2 mm区域CET明显变薄(P<0.05); 术后3 mo,角膜中央0-2 mm区域CET基本达术前水平。术后CD值升高,术后3 mo,0-2 mm区域CET与0-2 mm区域全层CD值呈正相关(r=0.256,P<0.05),2-5 mm区域CET与2-6 mm区域前层CD值呈正相关(r=0.319,P<0.05)。

    结论:角膜中央2 mm以内区域角膜上皮重塑需要3 mo时间; CET较薄的区域,术后角膜上皮重塑更快,术后早期增厚更多; 术后早期CD值较术前均增加,且部分区域CET与CD值呈正相关。

    Abstract:

    AIM: To evaluate the changes in corneal epithelial thickness(CET)and corneal optical density(CD)after smart pulse technology(SPT)-assisted transepithelial photorefractive keratectomy(TPRK)and analyze their correlation.

    METHODS: The prospective study included 60 patients(120 eyes)with myopia and myopic astigmatism who underwent SPT-TPRK in the ophthalmology department at the First Affiliated Hospital of Xinxiang Medical University between February and August 2023. Changes in CET and CD were evaluated preoperatively and at 1 wk, 1 and 3 mo postoperatively.

    RESULTS: A total of 14 cases(28 eyes)were lost to follow-up, and 3 patients(6 eyes)with postoperative haze were excluded from this study, resulting in a final inclusion of 43 patients(86 eyes). At 1 wk after SPT-TPRK, CET had statistically significantly thickened compared to preoperative levels(P<0.05), particularly in the CET at 0-2 mm central corneal area(P<0.05). At 1 mo after SPT-TPRK, the CET at 0-2 mm area had statistically significantly decreased(P<0.05). At 3 mo after SPT-TPRK, the CET at 0-2 mm had essentially reached preoperative levels. Postoperative CD values increased, with a positive correlation between CET in the 0-2 mm area and CD in the whole 0-2 mm area(r=0.256, P<0.05), and a positive correlation between CET in the 2-5 mm area and CD in the anterior 2-6 mm area(r=0.319, P<0.05).

    CONCLUSION: Corneal epithelial remodeling takes 3 mo in areas within 2 mm of the central cornea; areas with thinner CET have faster postoperative corneal epithelial remodeling and greater thickening in the early postoperative period; CD increases in the early postoperative period compared to the preoperative value, and in some areas, there is a positive correlation between CET and CD value.

    参考文献
    相似文献
    引证文献
引用本文

牛世阳,杨华,李彦,等. SPT辅助的TPRK术后角膜上皮厚度和光密度的变化及两者的相关性.国际眼科杂志, 2024,24(8):1308-1313.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2024-03-06
  • 最后修改日期:2024-06-18
  • 录用日期:
  • 在线发布日期: 2024-07-15
  • 出版日期:
文章二维码