褪黑素调节血管生成在眼底疾病中的研究进展

Research progress of melatonin in regulating angiogenesis in fundus diseases

摘要:

血管生成是涉及生理和病理过程的关键步骤，而促/抗血管生成因子又参与血管生成的始终，褪黑素是人脑松果体的合成产物，作用于人体各个系统。文章简述了褪黑素广泛的生物学作用及生理功能，归纳了褪黑素在不同条件下调控促/抗血管生成因子(如VEGF/MMP)在眼底疾病(如年龄相关性黄斑变性、糖尿病视网膜病变及中心性浆液性脉络膜视网膜病变等)中参与血管生成； 此外，还总结了褪黑素调控多种细胞因子、炎症因子及信号通路在眼底疾病中产生抗炎症、抗氧化、免疫反应等作用，从而得出了褪黑素在眼底血管疾病中的应用及潜在治疗，以期为治疗眼底疾病提供新的思路和治疗靶点。

Abstract:

Angiogenesis is a key step involving physiological and pathological processes, and pro/antiangiogenic factors are involved in angiogenesis throughout. Melatonin is a product synthesized by the pineal gland of the human brain and acts in various systems of the body. This article briefly describes the wide range of biological roles and physiological functions of melatonin, and summarizes that melatonin regulates pro-/anti-angiogenic factors(e.g., vascular endothelial growth factor/matrix metalloproteinase)under different conditions and is involved in angiogenesis in fundus diseases(e.g., age-related macular degeneration, diabetic retinopathy, and central serous choroioretinopathy); in addition, it also summarizes that melatonin regulates various cytokines, inflammatory factors and signaling pathways to produce anti-inflammatory, antioxidant and immune responses in fundus diseases, and thus obtaining the application and potential treatment of melatonin in fundus vascular diseases, with a view to providing new ideas and therapeutic targets for the treatment of fundus diseases.