环孢素A在眼表疾病中的应用及进展

Application and progress of cyclosporine A in ocular surface diseases

摘要:

环孢素A是一种具有强免疫抑制活性的环状多肽，作用机制广泛，包括免疫抑制作用、抗炎、抑制细胞凋亡、促进上皮愈合及杯状细胞功能恢复和增加泪液分泌，与修复眼表疾病的损伤密切相关。由于其疗效显著、抑制疾病复发且副作用较小，近年来，越来越多的眼表疾病如干眼、角膜移植术后排斥反应、春季角结膜炎、非感染性角膜炎、单纯疱疹病毒性角膜基质炎等在临床中使用环孢素A。然而，不同浓度和剂型的环孢素A对眼表炎症性疾病的治疗具有选择性差异。因此，为了系统地了解环孢素A对眼表疾病的影响，文章对其展开综述。

Abstract:

Cyclosporine A, a cyclic polypeptide, exhibits potent immunosuppressive activity and exerts its effects through various mechanisms including immunosuppression, anti-inflammatory, inhibition of apoptosis, promotion of epithelial healing and goblet cell function recovery, enhancement of tear secretion, and close association with ocular surface disease repair. Owing to its significant efficacy, inhibition of disease recurrence and few side effects, the clinical application of cyclosporine A in the management of ocular surface diseases, including dry eye, corneal graft rejection following penetrating keratoplasty, vernal keratoconjunctivitis, noninfective keratitis and herpes simplex virus keratitis, has witnessed a substantial rise in recent years. Nevertheless, variations exist in the management of ocular surface inflammatory diseases when utilizing distinct concentrations and dosage forms of cyclosporine A. Therefore, the paper provides an overview of impacts of cyclosporine A on ocular surface diseases.