青光眼局部用药的依从性及其障碍

Adherence and barriers to glaucoma topical medication

摘要:

目的：评估接受局部眼内压(IOP)降低治疗患者的药物依从性，并确定接受青光眼专家治疗的患者与接受普通眼科医生随访患者之间的药物依从性是否存在差异及导致依从性差的多个障碍。

方法：横断面调查研究。纳入2020-10/2021-02共54名患者行局部降眼压药物，且受试者完成了一份定制调查问卷，评估药物依从性及其障碍。

结果：约60%受试者未完全依从局部治疗。Pearson检验表明，依从性与是否接受青光眼专家的随访之间无显著关联(χ²=1.2468，P=0.5361)。其次，43%的受试者排斥滴眼液，Logistic回归分析显示，受试者表现出低依从性(β_î；=3.168，P=0.0367)。

结论：问卷可有效评估对局部降IOP治疗的药物依从性及其障碍。本研究药物依从率非常低，因此必须实施策略应对影响依从性最常见的障碍。

Abstract:

AIM: To evaluate medication adherence among patients taking topical intraocular pressure(IOP)lowering treatment and ascertain if there are differences in medication adherence between patients treated by a glaucoma specialist and those who are followed up by a general ophthalmologist. Furthermore, to identify multiple obstacles contributing to poor adherence.

METHODS: Cross-sectional survey study was conducted among a total of 54 patients, recruited from October 2020 to February 2021, who were using topical ocular hypotensive medication. Subjects completed a personalized questionnaire which was developed to evaluate medication adherence and its barriers.

RESULTS: Approximately 60% of our subject population were not completely adherent to topical treatment. Pearson's Chi-squared test demonstrated that there was no significant association between adherence and being followed up by a glaucoma specialist or not(χ²=1.2468, P=0.5361). Furthermore, 43% of participants expressed having problems with eyedrop instillation and Logistic regression analysis revealed that those subjects were significantly more likely to be low adherent to treatment(β_î=3.168, P=0.0367).

CONCLUSION: The questionnaire was effective to evaluate medication adherence to topical IOP lowering treatment and its barriers. The medication adherence rate found in this study was remarkably low, so several strategies must be put into practice to deal with the most common obstacles related to poor adherence.