目的：通过对近30 a原发性开角型青光眼(POAG)发病机制的相关文献进行计量学分析，了解该领域的发文情况、研究趋势及研究前沿和热点。

方法：检索1993-09-01/2023-09-01在中国知网(CNKI)和Web of Science(WOS)核心数据库已发表的关于POAG发病机制的相关文献986篇，运用CiteSpace(6.2.R.4)和VOSviewer(1.6.18)软件对检索到的文献进行知识图谱分析，分析内容包括发文量、作者、研究机构、国家/地区及关键词。

结果：美国发文量最多(243篇)，其次是中国(121篇)。发文量最多的国外研究机构是哈佛大学(37篇)，国内研究机构中山医科大学中山眼科中心、首都医科大学宣武医院眼科、北京医科大学第一医院眼科发文量并列第一。Louis R. Pasquale(21篇)是最高产的英文作者，王宁利是该领域最活跃的中国研究者。该领域研究的关键词包括小梁网、眼压、房水、糖皮质激素、血液流变学等。

结论：POAG发病机制的研究正处于蓬勃发展期，美国在该领域发文量最大，哈佛大学为该领域的领先研究机构。POAG研究领域的研究重点已经从结构方面转移到了基因层面，基因研究与中医治疗在该领域具有广泛的应用前景。

METHODS:A total of 986 relevant literatures on the pathogenesis of POAG published on the core databases of China National Knowledge Infrastructure(CNKI)and Web of Science(WOS)from 1 September 1993 to 1 September 2023 were retrieved. CiteSpace(6.2.R.4)and VOSviewer(1.6.18)software were used to conduct knowledge graph analysis on the retrieved literature, including publication volume, author, research institution, country/region, and keywords.

RESULTS:The United States(243 articles)has the highest number of publications, followed by China(121 articles). The foreign institution with the highest number of publications is Harvard University(37 articles), while domestic institutions such as Zhongshan Ophthalmic Center, Sun Yat-sen University, ophthalmology department of Xuanwu Hospital of Capital Medical University, and Peking University First Hospital tied for the highest number of publications. Louis R. Pasquale(21 articles)is the most prolific English author. Wang Ningli is the most active Chinese researcher in this field. Keywords include trabecular meshwork, intraocular pressure, aqueous humor, glucocorticoid, hemorheology, etc.

CONCLUSION: The research on the pathogenesis of POAG is in a period of vigorous development. The United States has the largest number of publications in this field, and Harvard University is a leading institution in this field. The research focus in the field of POAG has shifted from the structural aspect to the genetic level, and gene research and traditional Chinese medicine treatment have broad application prospects in this field.