新型冠状病毒引起的病毒性角膜炎病例观察

Case observation of viral keratitis caused by SARS-CoV-2

摘要:

目的：报告3例严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的病毒性角膜炎。

方法：对3例新冠感染确诊患者行裂隙灯、眼压、角膜荧光染色、前段照相、活体共聚焦显微镜(IVCM)和常规眼底筛查。治疗包括更昔洛韦眼用凝胶、人工泪液和糖皮质激素滴眼液。

结果：3例SARS-CoV-2角膜炎(SCK)患者经标准治疗后恢复良好。

结论：SARS-CoV-2角膜炎通常表现为角膜上皮下浸润，可导致角膜上皮下神经纤维密度降低和树突状细胞(DC)增加。抗病毒治疗联合糖皮质激素已被证明是有效的。

Abstract:

AIM: To report three cases of viral keratitis caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).

METHODS: Slit lamp, intraocular pressure, corneal fluorescence staining, anterior segment photography, in vivo confocal microscopy(IVCM), and routine fundus screening were performed in the three confirmed patients. Treatment involved Ganciclovir, artificial tears and glucocorticoid eye drops.

RESULTS: Three patients with SARS-CoV-2 keratitis(SCK)recovered well after standard treatment.

CONCLUSION: SARS-CoV-2 keratitis typically presents as corneal subepithelial infiltration and can result in a decrease in corneal subepithelial nerve fiber density and an increase in dendritic cells(DC). Antiviral therapy in combination with glucocorticoid has proven to be effective.