不同浓度氟米龙滴眼液治疗儿童重度混合型春季角结膜炎

Different concentrations of fluorometholone eye drops on the treatment of children with severe mixed vernal keratoconjunctivitis

摘要:

目的：观察不同浓度氟米龙滴眼液治疗儿童重度混合型春季角结膜炎的临床效果。

方法：选取2022-03/09于我院门诊就诊的重度混合型春季角结膜炎儿童患者50例100眼，随机分为两组，A组患者25例50眼给予0.1%氟米龙滴眼液联合0.05%环孢素滴眼液(Ⅱ)治疗； B组患者25例50眼给予0.02%氟米龙滴眼液联合0.05%环孢素滴眼液(Ⅱ)治疗。治疗1mo，观察两组患者SPEED问卷评分及角膜荧光素染色(FL)评分、泪膜破裂时间(TBUT)、泪液分泌试验(SⅠt)、眼红分析、非侵入式泪河高度(NIKTMH)、角膜光密度等眼部参数，记录不良反应发生情况。

结果：治疗1mo，两组患者SPEED评分、FL评分及眼红分析结果均有显著差异(均P<0.05)，TBUT、SⅠt及NIKTMH结果均无差异(均P>0.05)，但角膜不同深度、不同直径范围角膜光密度具有差异性(均P<0.05)。治疗1mo，两组患者眼压无显著差异(16.21±2.90mmHg vs 16.05±2.75mmHg，P>0.05)，且治疗过程中均未出现明显不良反应。

结论： 0.1%氟米龙滴眼液可有效治疗儿童重度混合型春季角结膜炎，效果优于0.02%氟米龙滴眼液。

Abstract:

AIM:To observe the clinical effect of different concentration of fluorometholone eye drops on severe mixed vernal keratoconjunctivitis in children.

METHODS: A total of 50 cases(100 eyes)of children with severe mixed vernal keratoconjunctivitis treated in the outpatient department of our hospital from March to September, 2022 were selected and randomly divided into two groups. Group A consisted of 25 cases(50 eyes)who were treated with 0.1% fluorometholone eye drops combined with 0.05% cyclosporine eye drops(Ⅱ), while 25 patients(50 eyes)in group B were treated with 0.02% fluorometholone eye drops combined with 0.05% cyclosporine eye drops(Ⅱ). After 1mo of treatment, SPEED questionnaire score, corneal fluorescein staining(FL)score, tear break-up time(TBUT), Schirmer I test(SⅠt), R-scan, non-invasive tear meniscus height(NIKTMH), corneal optical density and other ocular parameters of the two groups were observed, and the occurrence of adverse reactions were recorded.

RESULTS: After 1mo of treatment, there were significant differences in SPEED score, FL score and R-scan results between the two groups(all P<0.05), and no differences in TBUT, SⅠt and NIKTMH results(all P>0.05). However, there were statistical significance in corneal optical density in different corneal depth and diameter ranges(all P<0.05). After 1mo of treatment, there was no significant difference in intraocular pressure between the two groups(16.21±2.90mmHg vs. 16.05±2.75mmHg, P>0.05), and no obvious adverse reactions occurred during treatment.

CONCLUSION: The 0.1% fluorometholone eye drops can effectively treat severe mixed vernal keratoconjunctivitis in children, and its effect is better than 0.02% fluorometholone eye drops.